4.6 Article

Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Shayi Wu et al.

Summary: This study reveals the upregulation of ORAI2 in lymph node metastasis of gastric cancer, and its role in cell proliferation and migration. Clinical data shows a correlation between ORAI2-positive cells in gastric cancer tissues and poor prognosis. ORAI2 promotes metastasis of gastric cancer cells through activation of PI3K/Akt signaling pathway and focal adhesion disassembly at the cell's rear-edge.

CANCER RESEARCH (2021)

Article Cell Biology

Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling

Scott M. Emrich et al.

Summary: The study reveals the non-redundant functions of STIM1/2 and Orai1/2/3 proteins in ensuring the graded diversity of mammalian Ca2+ signaling. Additionally, it shows that the unactivated STIM1/2 inhibit IP3R-evoked Ca2+ release, with the inhibition gradually relieved as agonist intensity and STIM1/2 activation increase.

CELL REPORTS (2021)

Article Multidisciplinary Sciences

The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry

Pulak Kar et al.

Summary: Eukaryotic cells confine second messengers to spatially restricted subcompartments to avoid conflicting outcomes. The smallest signaling unit, Ca2+ nanodomain, is formed when Ca2+ channels open. NFAT1 tethered to scaffolding protein AKAP79 is activated by local Ca2+ entry, providing a mechanism to selectively recruit a transcription factor.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

The native ORAI channel trio underlies the diversity of Ca2+ signaling events

Ryan E. Yoast et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells

Elena Scremin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense

Derayvia Grimes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Cell Biology

Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels

Xuexin Zhang et al.

CELL CALCIUM (2020)

Article Biochemistry & Molecular Biology

Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization

Miriam Eckstein et al.

SCIENCE SIGNALING (2019)

Article Multidisciplinary Sciences

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Xuexin Zhang et al.

NATURE COMMUNICATIONS (2019)

Article Cell Biology

EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction

Letizia Albarran et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Multidisciplinary Sciences

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Martin Vaeth et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation

R. Diez-Bello et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

Article Biochemistry & Molecular Biology

Facilitation of Orai3 targeting and store-operated function by Orai1

Dalia Alansary et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Dynamic Assembly of a Membrane Signaling Complex Enables Selective Activation of NFAT by Orai1

Pulak Kar et al.

CURRENT BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Dynamic Response Diversity of NFAT Isoforms in Individual Living Cells

Nissan Yissachar et al.

MOLECULAR CELL (2013)

Article Oncology

Metastatic Behavior of Breast Cancer Subtypes

Hagen Kennecke et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Article Biochemistry & Molecular Biology

Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels

Wayne I. DeHaven et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties

Annette Lis et al.

CURRENT BIOLOGY (2007)

Article Multidisciplinary Sciences

Orai1 is an essential pore subunit of the CRAC channel

Murali Prakriya et al.

NATURE (2006)

Article Cell Biology

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

Christine Peinelt et al.

NATURE CELL BIOLOGY (2006)

Article Multidisciplinary Sciences

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

M. Vig et al.

SCIENCE (2006)

Review Cell Biology

Transcriptional regulation by calcium, calcineurin, and NFAT

PG Hogan et al.

GENES & DEVELOPMENT (2003)