4.6 Review

Molecular Targets and Emerging Therapies for Advanced Gallbladder Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Meeting Abstract Oncology

Zanidatamab (ZW25) in HER2-positive biliary tract cancers (BTCs): Results from a phase I study.

Funda Meric-Bernstam et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Feasibility of HER2-Targeted Therapy in Advanced Biliary Tract Cancer: A Prospective Pilot Study of Trastuzumab Biosimilar in Combination with Gemcitabine Plus Cisplatin

Hyehyun Jeong et al.

Summary: Unresectable or metastatic biliary tract cancer (BTC) has a poor prognosis with the standard gemcitabine and cisplatin (GemCis) regimen, but HER2-targeted therapy shows promising preliminary feasibility in patients with HER2-positive advanced BTC. This prospective study suggests the potential benefits of HER2-targeted combination chemotherapy in improving outcomes for patients with advanced BTC, warranting further investigation through future prospective randomised trials.

CANCERS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial

Angela Lamarca et al.

Summary: This study found that second-line FOLFOX chemotherapy can significantly improve overall survival in patients with advanced biliary tract cancer after progression on cisplatin and gemcitabine, indicating it should be considered as standard-of-care chemotherapy.

LANCET ONCOLOGY (2021)

Article Biotechnology & Applied Microbiology

Olaparib Treatment in a Patient with Advanced Gallbladder Cancer Harboring BRCA1 Mutation

Xiaofen Li et al.

Summary: This study presented a rare case of a 73-year-old gallbladder cancer patient diagnosed with metastases shortly after surgery, who underwent personalized treatment based on genetic sequencing and achieved a good response.

ONCOTARGETS AND THERAPY (2021)

Article Oncology

IMbrave 151: a randomized phase II trial of atezolizumab combined with bevacizumab and chemotherapy in patients with advanced biliary tract cancer

Stephen P. Hack et al.

Summary: Biliary tract cancers are aggressive tumors with poor prognosis, and a combination therapy targeting VEGF and PD-1/PD-L1 pathways may enhance anticancer immunity. The IMbrave 151 study is evaluating the effectiveness of atezolizumab in combination with chemotherapy and bevacizumab as a first-line treatment for advanced BTC, with a focus on biomarker analysis to assess treatment response.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

Article Oncology

The world-wide incidence of biliary tract cancer (BTC).

Huifen Wang et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Medicine, General & Internal

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer

Kohei Shitara et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Gastroenterology & Hepatology

Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance

Qing-Hai Li et al.

GASTROENTEROLOGY REPORT (2020)

Article Oncology

Molecular profile of BRCA-mutated biliary tract cancers

Gilbert Spizzo et al.

ESMO OPEN (2020)

Article Multidisciplinary Sciences

Genomic profiling reveals high frequency of DNA repair genetic aberrations in gallbladder cancer

Reham Abdel-Wahab et al.

SCIENTIFIC REPORTS (2020)

Review Biochemistry & Molecular Biology

Overview of current targeted therapy in gallbladder cancer

Xiaoling Song et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Pathology

Programmed death-ligand 1 expression and its correlation with clinicopathological parameters in gallbladder cancer

Ji Hye Kim et al.

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE (2020)

Article Medicine, General & Internal

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

S. Kopetz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Gastroenterology & Hepatology

Contemporary Tailored Oncology Treatment of Biliary Tract Cancers

Fiona Turkes et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2019)

Article Gastroenterology & Hepatology

Somatic genetic aberrations in gallbladder cancer: comparison between Chinese and US patients

Pingzhou Yang et al.

HEPATOBILIARY SURGERY AND NUTRITION (2019)

Article Oncology

Patterns and genomic correlates of PD-L1 expression in patients with biliary tract cancers

Kabir Mody et al.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2019)

Review Oncology

Overview of current systemic management of EGFR-mutant NSCLC

W. -H. Hsu et al.

ANNALS OF ONCOLOGY (2018)

Review Oncology

New developments in systemic therapy for advanced biliary tract cancer

Chigusa Morizane et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Targeting Angiogenesis in Biliary Tract Cancers: An Open Option

Valeria Simone et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Meeting Abstract Oncology

Pertuzumab plus trastuzumab for HER2-positive metastatic biliary cancer: Preliminary data from MyPathway.

Milind M. Javle et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Article Oncology

Global epidemiological trends and variations in the burden of gallbladder cancer

Chandrakanth Are et al.

JOURNAL OF SURGICAL ONCOLOGY (2017)

Article Medicine, General & Internal

Mutation analysis and copy number changes of KRAS and BRAF genes in Taiwanese cases of biliary tract cholangiocarcinoma

Wen-Chih Huang et al.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2017)

Review Oncology

New Horizons for Precision Medicine in Biliary Tract Cancers

Juan W. Valle et al.

CANCER DISCOVERY (2017)

Review Oncology

Molecular characteristics of biliary tract cancer

Davendra P. S. Sohal et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)

Article Gastroenterology & Hepatology

Response of BRCA1- mutated gallbladder cancer to olaparib: A case report

Yuan Xie et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Article Medicine, General & Internal

KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers

Masaaki Yokoyama et al.

JAPANESE CLINICAL MEDICINE (2016)

Review Oncology

HER2 expression status in diverse cancers: review of results from 37,992 patients

Min Yan et al.

CANCER AND METASTASIS REVIEWS (2015)

Article Medicine, General & Internal

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

Caroline Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Oncology

A genetic model for gallbladder carcinogenesis and its dissemination

S. G. Barreto et al.

ANNALS OF ONCOLOGY (2014)

Article Oncology

Phase I trial of everolimus, gemcitabine and cisplatin in patients with solid tumors

Brian A. Costello et al.

INVESTIGATIONAL NEW DRUGS (2014)

Meeting Abstract Oncology

Phase II study of everolimus monotherapy as first-line treatment in advanced biliary tract cancer: RADichol.

Yvonne H. Yeung et al.

JOURNAL OF CLINICAL ONCOLOGY (2014)

Article Medical Laboratory Technology

Immunohistochemical Expression of Phospho-mTOR Is Associated With Poor Prognosis in Patients With Gallbladder Adenocarcinoma

Pamela Leal et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2013)

Article Gastroenterology & Hepatology

Vascular endothelial growth factor single-nucleotide polymorphism in gall bladder cancer

Kumudesh Mishra et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

Article Medicine, General & Internal

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

Sunil Verma et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Oncology

Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma

Vikram Deshpande et al.

BMC CANCER (2011)

Article Oncology

Multi-Institutional Phase II Study of Selumetinib in Patients With Metastatic Biliary Cancers

Tanios Bekaii-Saab et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Review Oncology

Genetics of Biliary Tract Cancers and Emerging Targeted Therapies

Aram F. Hezel et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Article Medicine, General & Internal

Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer.

Juan Valle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Oncology

A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer

Ramesh K. Ramanathan et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2009)

Article Medicine, General & Internal

Lapatinib plus capecitabine for HER2-positive advanced breast cancer

Charles E. Geyer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Oncology

The hedgehog signaling pathway in cancer

Marie Evangelista et al.

CLINICAL CANCER RESEARCH (2006)

Article Oncology

Phase II study of erlotinib in patients with advanced biliary cancer

Philip A. Philip et al.

JOURNAL OF CLINICAL ONCOLOGY (2006)

Article Medicine, General & Internal

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

DJ Slamon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)