期刊
CANCERS
卷 13, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/cancers13215407
关键词
indirect carcinogenesis; bovine meat and milk factors (BMMF); chronic zoonosis
类别
资金
- Deutsches Krebsforschungszentrum (German Cancer Center)
- Oryx Alpha
This manuscript emphasizes the different mechanistic aspects of infectious agents contributing to human cancers by direct or indirect interactions. Cancers induced by direct infectious carcinogens commonly increase under immunosuppression, whereas the cancer risk by indirect carcinogens is reduced. This influences their responses to preventive and therapeutic interferences.
Simple SummaryThis manuscript emphasizes the mechanistic differences of infectious agents contributing to human cancers either by direct or indirect interactions. The epidemiology of cancers linked to direct carcinogens differs (e.g., response to immunosuppression) from those cancers linked with indirect infectious interactions. We discuss their role in colon, breast, and prostate cancers and type II diabetes mellitus. A brief discussion covers the potential role of BMMF (bovine meat and milk factor) infections in acute myeloid leukemia.Exemplified by infections with bovine meat and milk factors (BMMFs), this manuscript emphasizes the different mechanistic aspects of infectious agents contributing to human cancers by direct or indirect interactions. The epidemiology of cancers linked to direct carcinogens (e.g., response to immunosuppression) differs from those cancers linked with indirect infectious interactions. Cancers induced by direct infectious carcinogens commonly increase under immunosuppression, whereas the cancer risk by indirect carcinogens is reduced. This influences their responses to preventive and therapeutic interferences. In addition, we discuss their role in colon, breast and prostate cancers and type II diabetes mellitus. A brief discussion covers the potential role of BMMF infections in acute myeloid leukemia.
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