4.6 Article

Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology

期刊

出版社

BMC
DOI: 10.1186/s40478-021-01275-7

关键词

Alzheimer's disease; Neurofibrillary tangles; Ex vivo MRI; Neurodegeneration; Biomarkers; Co-morbidities

资金

  1. National Institute of Health [R01 EB017255, R01 AG056014, P30 AG010124, R01 AG054519, AG017586]
  2. UCLM Travel Grant
  3. UCLM
  4. Alzheimer's Association [AARF-19-615258]

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The study revealed a close association between tau neurofibrillary tangle pathology and neurodegeneration in the medial temporal lobe. Significant correlations were found between regional thickness in the entorhinal cortex and stratum radiatum lacunosum moleculare and tau pathology severity, especially in cases with low levels of TDP-43 pathology.
Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer's disease (AD). To elucidate patterns of structural change in the MTL specifically associated with tau pathology, we compared high-resolution ex vivo MRI scans of human postmortem MTL specimens with histology-based pathological assessments of the MTL. MTL specimens were obtained from twenty-nine brain donors, including patients with AD, other dementias, and individuals with no known history of neurological disease. Ex vivo MRI scans were combined using a customized groupwise diffeomorphic registration approach to construct a 3D probabilistic atlas that captures the anatomical variability of the MTL. Using serial histology imaging in eleven specimens, we labelled the MTL subregions in the atlas based on cytoarchitecture. Leveraging the atlas and neuropathological ratings of tau and TAR DNA-binding protein 43 (TDP-43) pathology severity, morphometric analysis was performed to correlate regional MTL thickness with the severity of tau pathology, after correcting for age and TDP-43 pathology. We found significant correlations between tau pathology and thickness in the entorhinal cortex (ERC) and stratum radiatum lacunosum moleculare (SRLM). When focusing on cases with low levels of TDP-43 pathology, we found strong associations between tau pathology and thickness in the ERC, SRLM and the subiculum/cornu ammonis 1 (CA1) subfields of the hippocampus, consistent with early Braak stages.

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