期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/jcm10245857
关键词
COVID; SARS-CoV; prolonged-release melatonin 2 mg; delirium; insomnia
The study found that COVID-19 pneumonia patients treated with prolonged-release melatonin 2 mg had a shorter duration of non-invasive ventilation, shorter stay in sub-intensive care, and lower incidence of delirium compared to untreated patients. These results suggest potential benefits of prolonged-release melatonin 2 mg therapy in COVID-19 treatment.
Background: we have observed the effect of insomnia treatment in clinical and prognostic differences of patients admitted for COVID-19 pneumonia in respiratory sub-intensive units that were administered a prolonged-release melatonin 2 mg (PRM 2 mg) therapy versus a group of patients out of therapy. Materials and Methods: We evaluated 40 patients on prolonged-release melatonin 2 mg (PRM 2 mg) therapy versus a control group of 40 patients out of therapy. Results: patients in the PRM 2 mg group had a shorter duration of therapy with non-invasive ventilation (5.2 +/- 3.0 vs. 12.5 +/- 4.2; p < 0.001), with a shorter stay in sub-intensive care (12.3 +/- 3.2 vs. 20.1 +/- 6.1; p < 0.001), and, therefore, a shorter overall duration of hospitalization (31.3 +/- 6.8 vs. 34.3 +/- 6.9 p = 0.03). In addition, a lower incidence of delirium was found (2.2 +/- 1.1 vs. 3.3 +/- 1.3; p < 0.001). Conclusions: A significant increase in sleep hours and a reduction in delirium episodes occurs in hospitalized insomniac patients treated with PRM 2 mg, compared to untreated patients. Based on these preliminary results, we can assume that there are benefits of prolonged-release melatonin 2 mg in COVID-19 therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据