期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/jcm11010139
关键词
CPAP (continuous positive air pressure); PSG (polysomnography); OSA (obstructive sleep apnoea); adherence
资金
- Polish Ministry of Science and Higher Education [0067/DIA/2018/47]
- National Science Centre, Poland [2018/31/N/NZ5/03931]
This study investigated factors contributing to treatment failure and poor compliance in patients with obstructive sleep apnoea/hypopnoea syndrome (OSA) using continuous positive airway pressure (CPAP) treatment. Among the 400 patients analyzed, various reasons were identified for patients not starting or discontinuing CPAP treatment. Only mild OSA (AHI < 15) was strongly associated with long-term CPAP treatment failure.
Continuous positive airway pressure (CPAP) has been the standard treatment of obstructive sleep apnoea/hypopnoea syndrome (OSA) for almost four decades. Though usually effective, this treatment suffers from poor long-term compliance. Therefore, the aim of our one centre retrospective study was to assess factors responsible for treatment failure and long-term compliance. Four hundred subsequent patients diagnosed with OSA and qualified for CPAP treatment were chosen from our database and compliance data were obtained from medical charts. Many differing factors kept patients from starting CPAP or led to termination of treatment. Overall, almost half of patients ended treatment during the mean time of observation of 3.5 years. Survival analysis revealed that 25% of patients failed at a median time of 38.2 months. From several demographic and clinical covariates in Cox's hazard model, only the presence of a mild OSA, i.e., AHI (apnoea/hypopnoea index) below 15/h was a factor strongly associated with long term CPAP failure. The compliance results of our study are in line with numerous studies addressing this issue. Contrary to them, some demographic or clinical variables that we used in our survival model were not related to CPAP adherence.
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