CGRP Inhibitors and Oxidative Stress Biomarkers in Resistant Migraine: A Real-Life Study with Erenumab, Fremanezumab, and Galcanezumab

Article Clinical Neurology

Update on Calcitonin Gene-Related Peptide Antagonism in the Treatment of Migraine

Edoardo Caronna et al.

Summary: CGRP is revolutionizing headache medicine by providing insights into migraine pathophysiology and therapeutic pathways. While clinical trials show promising results, real-world data are needed to further validate the findings.

NEUROLOGIC CLINICS (2021)

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Article Clinical Neurology

Enhanced Hemodynamic and Clinical Response to αCGRP in Migraine Patients-A TCD Study

Darja Visocnik et al.

Summary: The study showed that patients with migraine have significantly higher vascular responses to h alpha CGRP, indicating a stronger association with CGRP-induced headache and greater likelihood of sensitization.

FRONTIERS IN NEUROLOGY (2021)

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Article Medicine, General & Internal

Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

Ciro De Luca et al.

Summary: Migraine patients exhibit differences in processing visual stimuli and visual cortex activity compared to controls. The S index may serve as a potential biomarker for the migraine cycle and cortical sensitization, but further data are needed for confirmation.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Clinical Neurology

Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance

Simona Sacco et al.

Summary: The study found that resistant and refractory migraine patients are commonly seen in clinical practice, but many physicians lack confidence in managing them. Patients are often not referred to more specialized centers, indicating unmet needs in the field.

JOURNAL OF HEADACHE AND PAIN (2021)

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Article Nutrition & Dietetics

Social Distancing in Chronic Migraine during the COVID-19 Outbreak: Results from a Multicenter Observational Study

Vincenzo Di Stefano et al.

Summary: The study revealed that the restrictions implemented during the pandemic had negative effects on the physical activity levels and sleep quality of migraine patients, highlighting the importance of assessing physical activity and sleep quality to improve quality of life.

NUTRIENTS (2021)

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Article Medicine, General & Internal

Urinary Proteomics Reveals Promising Biomarkers in Menstrually Related and Post-Menopause Migraine

Elisa Bellei et al.

Summary: This study compared the urinary proteome of women suffering from different types of migraines with non-headache women, identifying potential biomarkers related to the pathophysiology of migraines. The findings may offer insights into better diagnosis and treatment of migraines.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Medicine, General & Internal

Changes in Cerebral Blood Flow after Erenumab Treatment in Good and Non-Responders-A Pilot Study of Migraine Patients

Magdalena Nowaczewska et al.

Summary: This study compared changes in cerebral blood flow between good responders and non-responders to erenumab treatment for migraine prevention. The results showed that good responders had lower baseline blood flow velocity in certain arteries, which significantly increased after treatment, suggesting that lower baseline blood flow velocity may predict efficacy of erenumab.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Cell Biology