期刊
JOURNAL OF CLINICAL MEDICINE
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jcm11041063
关键词
heart failure; HFpEF; greater splanchnic nerve ablation
资金
- Axon Therapies, Inc. (NY, USA)
- Czech Ministry of Health research grand-DRO (NNH) [00023884, IG 170201, IG 150504]
In patients with heart failure, permanent ablation of the right greater splanchnic nerve leads to a significant reduction in intracardiac filling pressures during exercise within 24 hours following the procedure.
Background: Permanent ablation of the right greater splanchnic nerve (GSN) has previously been demonstrated to improve quality of life and functional outcomes, as well as reduce abnormally high intracardiac filling pressures, in patients with heart failure with preserved ejection fraction (HFpEF) at 1, 3 and 12 months following the procedure. We hypothesize that hemodynamic changes that ensue from surgical right GSN ablation would be apparent as early as 24 h after the medical intervention. Methods and Results: This is a prespecified analysis of a single-arm, two-center, open-label study evaluating the effects of right GSN ablation via thoracoscopic surgery in HFpEF patients with pulmonary capillary wedge pressure (PCWP) >= 15 mmHg at rest or >= 25 mmHg with supine cycle ergometry. A total of seven patients (median age 67 years, 29% female) underwent GSN removal followed by invasive right heart catheterization within 24 h. GSN ablation resulted in a significant reduction in PCWP 24 h after the procedure compared to baseline for both 20 W exercise (baseline (28.0 +/- 4.3 mmHg) to 24 h (19.6 +/- 6.9 mmHg); p = 0.0124) and peak exercise (baseline (25.6 +/- 2.4 mmHg) to 24 h (17.4 +/- 5.9 mmHg); p = 0.0025). There were no significant changes in resting or leg-up hemodynamics. Conclusions: Permanent right GSN ablation leads to a reduction in intracardiac filling pressures during exercise, apparent as early as 24 h following the procedure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据