期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/jcm10225463
关键词
PDAC biomarkers; early diagnostic; ELISA
资金
- Department of Digestive Tract Diseases, Medical University of Lodz [503/1-002-01/503-11-001-19-00]
The poor prognosis of PDAC is attributed to a lack of effective treatment and late diagnosis, while early detection could significantly decrease mortality. Ideal biomarkers for PDAC should be cost-effective, detectable in easily accessible biological material, and present in sufficient concentration in the earliest possible phase of the disease.
A poor PDAC prognosis is due to a lack of effective treatment and late diagnosis. The early detection of PDAC could significantly decrease mortality and save lives. Idealbiomarkers for PDAC should be cost-effective, detectable in easily accessible biological material, and present in sufficient concentration in the earliest possible phase of the disease. This review addresses newly selected, simple protein biomarkers-new ones such as thrombospondin-2, insulin-linked binding protein 2, lysophosphatidic acid, and autotaxin and conventional ones such as Ca19-9, inflammatory factors, and coagulation factors. Their possible use in the early detection of PDAC, differentiation from benign diseases, prognosis, and treatment response prediction is discussed. We also address the usefulness of possible combinations of biomarkers in diagnostic panels.
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