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Article
Medicine, General & Internal
Zhitao Wang et al.
Summary: M-MDSCs are significantly increased in DLBCL patients and are positively correlated with tumor progression and negatively correlated with overall survival. IL-35 mediates the accumulation of M-MDSCs in DLBCL patients, and anti-IL-35 treatment reduces the levels of M-MDSCs significantly. Targeting M-MDSCs may be a promising therapeutic strategy for DLBCL patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Alejandro Olivares-Hernandez et al.
Summary: Myeloid-derived suppressor cells (MDSCs) are immature myeloid lineage cells that have been associated with tumor processes, including resistance to immunotherapy. Current research suggests that MDSCs, in combination with immune checkpoint inhibitors (ICIs), may be used to treat various hematological neoplasms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Christos Demosthenous et al.
Summary: MDSCs play a role in suppressing GVHD toxicity after allo-HCT, but their impact on the GVL effect is not fully defined. Studying MDSC metabolism and inflammasome signaling pathways may help elucidate their function in GVHD pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Christophe Vanhaver et al.
Summary: MDSCs expand during pathological conditions and are associated with poor clinical outcomes in cancer patients. However, studying MDSC immunosuppression is challenging due to their rarity, short lifespan, heterogeneity, poor viability after freezing, and lack of specific markers. While some immunosuppressive mechanisms have been well-documented in mice, direct evidence is still lacking in humans.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Suncica Kapor et al.
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Iosif Papafragkos et al.
Summary: Myeloid-derived suppressor cells (MDSCs) are potent regulators of the immune system, playing a role in cancer but their specific contribution to lymphomas remains unclear. This review focuses on MDSCs in lymphomas, discussing literature and lessons learned from animal models, and highlights future research directions and challenges in understanding the immune system complexities in malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Hematology
Nikoleta Bizymi et al.
Article
Oncology
Dmitry I. Gabrilovich
CANCER IMMUNOLOGY RESEARCH
(2017)
