期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/jcm10215058
关键词
asthma; chronic obstructive pulmonary disease; airway remodelling; emphysema; quantitative computed tomography
资金
- PolishMinistry of Science andHigher Education-Diamond Grant Award [DI 2013 018143]
This study found that the thickness of the bronchial wall was greater in the SA-PAL group than in the COPD group, with the lowest lung density observed in the SA-PAL group and a higher percentage of low-attenuation volume compared to the healthy volunteer group. Severe asthma with persistent airflow limitation and COPD become similar in terms of functional and morphological dimensions over time, both showing emphysema qualities.
Background: Severe asthma with persistent airflow limitation (SA-PAL) and chronic obstructive pulmonary disease (COPD) are characterised by irreversible airflow limitation and the remodelling of the airways. The phenotypes of the diseases overlap and may cause diagnostic and therapeutic concerns. Methods: There were 10 patients with SA-PAL, 11 patients with COPD, and 10 healthy volunteers (HV) enrolled in this study. The patients were examined with a 128-multislice scanner at full inspiration. Measurements were taken from the third to ninth bronchial generations. Results: The thickness of the bronchial wall was greater in the SA-PAL than in the COPD group for most bronchial generations (p < 0.05). The mean lung density was the lowest in the SA-PAL group (-846 HU), followed by the COPD group (-836 HU), with no statistical difference between these two groups. The low-attenuation volume percentage (LAV% < -950 HU) was significantly higher in the SA-PAL group (15.8%) and COPD group (10.4%) compared with the HV group (7%) (p = 0.03). Conclusion: Severe asthma with persistent airflow limitation and COPD become similar with time within the functional and morphological dimensions. Emphysema qualities are present in COPD and in SA-PAL patients.
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