期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/jcm10245938
关键词
dyslipidemia; hypercholesterolemia; coronary artery disease; myocardial infarction; secondary prevention; guidelines adherence
资金
- Amgen
The DAUSSET study aimed to describe clinical practices for LDL cholesterol control in very high-risk CAD patients. Results showed that more than half of the patients did not achieve the LDL cholesterol goal, indicating insufficient lipid control in this patient population. Further improvement in prevention of cardiovascular events in these patients may require better education and more intensive lipid-lowering therapy.
Introduction: Patients with established coronary artery disease (CAD) are at very high risk for cardiovascular events. Methods: The DAUSSET study is a national, multicenter, non-interventional study that included very high-risk CAD patients followed by French cardiologists. It aimed to describe real-life clinical practices for low-density lipoprotein (LDL) cholesterol control in the secondary prevention of CAD. Results: A total of 912 patients (mean age, 65.4 years; men, 76.1%; myocardial infarction, 69.4%; first episode, 80.1%) were analyzed. The LDL cholesterol goal was 70 mg/dL in most cases (84.9%). The LDL cholesterol goal <70 mg/dL was achieved in 41.7% of patients. Of the 894 (98.0%) patients who received lipid-lowering therapy, 81.2% had been treated more intensively after the cardiac event, 27.0% had been treated less intensively and 13.1% had been maintained. Participating cardiologists were very satisfied or satisfied with treatment response in 72.6% of patients. Moderate satisfaction or dissatisfaction with lipid-lowering therapy was related to not achieving objectives (100%), treatment inefficacy (53.7%), treatment intolerance (23.4%) and poor adherence (12.3%). Conclusion: These real-world results show that lipid control in very high-risk patients remains insufficient. More than half of the patients did not achieve the LDL cholesterol goal. Prevention of cardiovascular events in these very high-risk patients could be further improved by better education and more intensive lipid-lowering therapy.
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