期刊
MSYSTEMS
卷 6, 期 6, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/mSystems.00953-21
关键词
protein secretion; interspecies interaction; effector; PAAR; T6SS; protein secretion
类别
资金
- National Key R&D Program of China [2020YFA0907200]
- National Natural Science Foundation of China [31770082, 32030001]
The type VI secretion system injects a rigid inner tube into cells using a contractile outer sheath, with the tip often decorated by a PAAR-repeat protein. PAAR proteins have diverse functions, acting as toxins or carriers for interacting toxins, highlighting the need for future research on their functions.
The type VI secretion system (T6SS) belongs to the evolutionarily related group of contractile injection systems that employ a contractile outer sheath to inject a rigid spear-like inner tube into target bacterial and eukaryotic cells. The tip of the rigid tube is often decorated by a PAAR-repeat protein as a key structural component. Many members of the PAAR protein family can also have additional and diverse functions by serving as toxins for those with extended domains or as carriers for interacting toxins. A plethora of toxin modules or modules of unknown functions have been bioinformatically predicted to be associated with PAAR either as a fused domain or as an interacting partner, and yet only a small number of PAAR proteins have been studied, highlighting the exciting and dire need for future research to better understand the diverse PAAR-mediated functions.
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