4.6 Review

The role of pathological tau in synaptic dysfunction in Alzheimer's diseases

期刊

TRANSLATIONAL NEURODEGENERATION
卷 10, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s40035-021-00270-1

关键词

Pathological tau; Synaptic dysfunction; Synaptic plasticity; Alzheimer's disease

资金

  1. National Natural Science Foundation of China [82030032, 32070960, 81871108, 81760221, 81960221, 81660209]
  2. National Science & Technology Fundamental Resource Investigation Program of China [2018FY100903]
  3. Science and Technology Project Founded by the Education Department of Jiangxi Province [GJJ201834]

向作者/读者索取更多资源

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, with synaptic dysfunction recognized as the main cause of cognitive impairments. Pathological tau is suggested to induce synaptic dysfunction in various ways, contributing to cognitive decline in AD. Exploring the mechanism by which pathological tau impairs synaptic function is crucial for developing novel therapeutic strategies for AD.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-beta (A beta) overload and hyperphosphorylated tau accumulation in the brain. Synaptic dysfunction, an important pathological hallmark in AD, is recognized as the main cause of the cognitive impairments. Accumulating evidence suggests that synaptic dysfunction could be an early pathological event in AD. Pathological tau, which is detached from axonal microtubules and mislocalized into pre- and postsynaptic neuronal compartments, is suggested to induce synaptic dysfunction in several ways, including reducing mobility and release of presynaptic vesicles, decreasing glutamatergic receptors, impairing the maturation of dendritic spines at postsynaptic terminals, disrupting mitochondrial transport and function in synapses, and promoting the phagocytosis of synapses by microglia. Here, we review the current understanding of how pathological tau mediates synaptic dysfunction and contributes to cognitive decline in AD. We propose that elucidating the mechanism by which pathological tau impairs synaptic function is essential for exploring novel therapeutic strategies for AD.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据