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ARCHIVES OF TOXICOLOGY (2015)
3D spheroid cultures improve the metabolic gene expression profiles of HepaRG cells
Yu Takahashi et al.
BIOSCIENCE REPORTS (2015)
Mitochondrial (dys)function - a factor underlying the variability of efavirenz-induced hepatotoxicity?
M. Polo et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
The Combination of Anti-CTLA-4 and PD1-/- Mice Unmasks the Potential of Isoniazid and Nevirapine To Cause Liver Injury
Alastair Mak et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2015)
Preventing Drug-Induced Liver Injury: How Useful Are Animal Models?
Francois Ballet
DIGESTIVE DISEASES (2015)
The application of engineered liver tissues for novel drug discovery
Christine Lin et al.
EXPERT OPINION ON DRUG DISCOVERY (2015)
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study
Naga Chalasani et al.
GASTROENTEROLOGY (2015)
Treatment of PD-1-/- Mice With Amodiaquine and Anti-CTLA4 Leads to Liver Injury Similar to Idiosyncratic Liver Injury in Patients
Imir G. Metushi et al.
HEPATOLOGY (2015)
Enhancing the Functional Maturity of Induced Pluripotent Stem Cell-Derived Human Hepatocytes by Controlled Presentation of Cell-Cell Interactions In Vitro
Dustin R. Berger et al.
HEPATOLOGY (2015)
Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment
Mala Chakraborty et al.
HEPATOLOGY (2015)
A novel humanized mouse model for autoimmune hepatitis and the association of gut microbiota with liver inflammation
Muhammed Yuksel et al.
HEPATOLOGY (2015)
Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model
Shengbiao Li et al.
HEPATOLOGY (2015)
Drug-induced liver injury: Interactions between drug properties and host factors
Minjun Chen et al.
JOURNAL OF HEPATOLOGY (2015)
Liver injury in patients with DRESS: A clinical study of 72 cases
I-Chun Lin et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)
Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis
Fatemeh Momen-Heravi et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2015)
Integrative Modeling Strategies for Predicting Drug Toxicities at the eTOX Project
Ferran Sanz et al.
MOLECULAR INFORMATICS (2015)
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
Sandra March et al.
NATURE PROTOCOLS (2015)
Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays
Falgun Shah et al.
TOXICOLOGICAL SCIENCES (2015)
Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells
Si Chen et al.
TOXICOLOGICAL SCIENCES (2015)
Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing
Jingtao Lu et al.
TOXICOLOGICAL SCIENCES (2015)
Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes
Brenton R. Ware et al.
TOXICOLOGICAL SCIENCES (2015)
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
Rowena L. C. Sison-Young et al.
TOXICOLOGICAL SCIENCES (2015)
Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related
Kevin M. Beggs et al.
TOXICOLOGY (2015)
The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death
Laleh Kamalian et al.
TOXICOLOGY IN VITRO (2015)
Data-driven identification of structural alerts for mitigating the risk of drug-induced human liver injuries
Ruifeng Liu et al.
JOURNAL OF CHEMINFORMATICS (2015)
FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach
Weiqiang Lu et al.
SCIENTIFIC REPORTS (2015)
Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities
Ran-Ran Zhang et al.
STEM CELL RESEARCH & THERAPY (2015)
Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver
Hiroshi Yamazaki et al.
TOXICOLOGY RESEARCH (2015)
Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells
Elisa Pfeiffer et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2015)
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model
Jung Woo Eun et al.
JOURNAL OF APPLIED TOXICOLOGY (2015)
Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset
Imir G. Metushi et al.
JOURNAL OF IMMUNOTOXICOLOGY (2015)
Open TG-GATEs: a large-scale toxicogenomics database
Yoshinobu Igarashi et al.
NUCLEIC ACIDS RESEARCH (2015)
MITOsymA®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics
Y. Yang et al.
PHARMACEUTICAL RESEARCH (2015)
Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice
Chise Tateno et al.
PLOS ONE (2015)
Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model
Nico Scheer et al.
DRUG METABOLISM AND DISPOSITION (2015)
Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats
Azumi Iida et al.
DRUG METABOLISM AND DISPOSITION (2015)
Microengineered Liver Tissues for Drug Testing
Salman R. Khetani et al.
JALA (2015)
Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters
Theresa V. Nguyen et al.
DRUG METABOLISM AND DISPOSITION (2015)
Chimeric TK-NOG Mice: A Predictive Model for Cholestatic Human Liver Toxicity
Dan Xu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Human Hepatocytes and Hematolymphoid Dual Reconstitution in Treosulfan-Conditioned uPA-NOG Mice
Tanuja L. Gutti et al.
AMERICAN JOURNAL OF PATHOLOGY (2014)
A Micropatterned Hepatocyte Coculture Model for Assessment of Liver Toxicity Using High-Content Imaging Analysis
O. Joseph Trask et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2014)
Bulk autophagy, but not mitophagy, is increased in cellular model of mitochondrial disease
Maria Moran et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Toward predictive models for drug-induced liver injury in humans: are we there yet?
Minjun Chen et al.
BIOMARKERS IN MEDICINE (2014)
Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury
Lisl K. M. Shoda et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2014)
Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics
Seigo Sanoh et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2014)
Pluripotent stem cell-derived hepatocyte-like cells
R. E. Schwartz et al.
BIOTECHNOLOGY ADVANCES (2014)
RNA-Seq gene expression profiling of HepG2 cells: the influence of experimental factors and comparison with liver tissue
Alexander V. Tyakht et al.
BMC GENOMICS (2014)
Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming
Yuanyuan Du et al.
CELL STEM CELL (2014)
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes
Pengyu Huang et al.
CELL STEM CELL (2014)
Heps with Pep: Direct Reprogramming into Human Hepatocytes
Ludovic Vallier
CELL STEM CELL (2014)
Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity
K. Yang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2014)
Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism
Takako Ohkura et al.
DRUG METABOLISM AND PHARMACOKINETICS (2014)
Bioactivation of drugs in the skin: relationship to cutaneous adverse drug reactions
Amy M. Sharma et al.
DRUG METABOLISM REVIEWS (2014)
Competency of different cell models to predict human hepatotoxic drugs
M. Jose Gomez-Lechon et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2014)
Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury
Mercedes Robles-Diaz et al.
GASTROENTEROLOGY (2014)
Human Drug-Induced Liver Injury Severity Is Highly Associated With Dual Inhibition of Liver Mitochondrial Function and Bile Salt Export Pump
Michael D. Aleo et al.
HEPATOLOGY (2014)
Hybrid in silico models for drug-induced liver injury using chemical descriptors and in vitro cell-imaging information
Xiang-Wei Zhu et al.
JOURNAL OF APPLIED TOXICOLOGY (2014)
Direct Reprogramming of Human Fibroblasts to Hepatocyte-Like Cells by Synthetic Modified mRNAs
Kamen P. Simeonov et al.
PLOS ONE (2014)
Drug-Induced Liver Injury and Drug Development: Industry Perspective
Arie Regev
SEMINARS IN LIVER DISEASE (2014)
Extensive double humanization of both liver and hematopoiesis in FRGN mice
Elizabeth M. Wilson et al.
STEM CELL RESEARCH (2014)
A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans
Frida Gustafsson et al.
TOXICOLOGICAL SCIENCES (2014)
Utilization of Causal Reasoning of Hepatic Gene Expression in Rats to Identify Molecular Pathways of Idiosyncratic Drug-Induced Liver Injury
Daphna Laifenfeld et al.
TOXICOLOGICAL SCIENCES (2014)
A Systems Biology Approach Utilizing a Mouse Diversity Panel Identifies Genetic Differences Influencing Isoniazid-Induced Microvesicular Steatosis
Rachel J. Church et al.
TOXICOLOGICAL SCIENCES (2014)
Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines
Thibault Bricks et al.
TOXICOLOGY IN VITRO (2014)
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma
W. Mattes et al.
TOXICOLOGY LETTERS (2014)
Development of a cell-based assay system considering drug metabolism and immune-and inflammatory-related factors for the risk assessment of drug-induced liver injury
Azusa Yano et al.
TOXICOLOGY LETTERS (2014)
Use of a systems model of drug-induced liver injury (DILIsym®) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice
Brett A. Howell et al.
TOXICOLOGY LETTERS (2014)
The importance of both fibroblasts and keratinocytes in a bilayered living cellular construct used in wound healing
Abigail M. Wojtowicz et al.
WOUND REPAIR AND REGENERATION (2014)
Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies
John R. Foster et al.
XENOBIOTICA (2014)
Valproate-Induced Liver Injury: Modulation by the Omega-3 Fatty Acid DHA Proposes a Novel Anticonvulsant Regimen
Marwa A. Abdel-Dayem et al.
DRUGS IN R&D (2014)
Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing
Dan Xu et al.
PLOS MEDICINE (2014)
Risk Factors for Development of Cholestatic Drug-Induced Liver Injury: Inhibition of Hepatic Basolateral Bile Acid Transporters Multidrug Resistance-Associated Proteins 3 and 4
Kathleen Koeck et al.
DRUG METABOLISM AND DISPOSITION (2014)
The Role of Bile Salt Export Pump Gene Repression in Drug-Induced Cholestatic Liver Toxicity
Brandy Garzel et al.
DRUG METABOLISM AND DISPOSITION (2014)
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved
Laia Tolosa et al.
ARCHIVES OF TOXICOLOGY (2013)
ER stress-induced cell death mechanisms
Renata Sano et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing
Kazuo Takayama et al.
BIOMATERIALS (2013)
Drug reaction with eosinophilia and systemic symptoms: is cutaneous phenotype a prognostic marker for outcome? A review of clinicopathological features of 27 cases
S. Walsh et al.
BRITISH JOURNAL OF DERMATOLOGY (2013)
Human Precision-Cut Liver Slices as an ex Vivo Model to Study Idiosyncratic Drug-Induced Liver Injury
Mackenzie Hadi et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2013)
Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering
M. Donato et al.
CURRENT DRUG METABOLISM (2013)
Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations
Laura P. James et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2013)
Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity
Tom De Bruyn et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2013)
Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland
Einar S. Bjornsson et al.
GASTROENTEROLOGY (2013)
Gene expression signature of human HepG2 cell line
S. Costantini et al.
GENE (2013)
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells
Sebastien Antherieu et al.
HEPATOLOGY (2013)
Human Leukocyte Antigen (HLA)-B☆57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury
Manal M. Monshi et al.
HEPATOLOGY (2013)
ER stress in human hepatic cells treated with Efavirenz: Mitochondria again
Nadezda Apostolova et al.
JOURNAL OF HEPATOLOGY (2013)
An Updated Review on Drug-Induced Cholestasis: Mechanisms and Investigation of Physicochemical Properties and Pharmacokinetic Parameters
Kyunghee Yang et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
Ilka Wagner et al.
LAB ON A CHIP (2013)
Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury
Eugenia Ulzurrun et al.
LIVER INTERNATIONAL (2013)
Vascularized and functional human liver from an iPSC-derived organ bud transplant
Takanori Takebe et al.
NATURE (2013)
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy
Feng Li et al.
NATURE MEDICINE (2013)
HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity
Camilla Stephens et al.
PLOS ONE (2013)
Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans
Salman R. Khetani et al.
TOXICOLOGICAL SCIENCES (2013)
Metabolomics-on-a-Chip of Hepatotoxicity Induced by Anticancer Drug Flutamide and Its Active Metabolite Hydroxyflutamide Using HepG2/C3a Microfluidic Biochips
Leila Choucha Snouber et al.
TOXICOLOGICAL SCIENCES (2013)
Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)
Jenny M. Pedersen et al.
TOXICOLOGICAL SCIENCES (2013)
A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity
Radina Kostadinova et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)
Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells
Marc Le Vee et al.
TOXICOLOGY IN VITRO (2013)
A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays
James Hynes et al.
TOXICOLOGY IN VITRO (2013)
Human induced pluripotent stem cells and their use in drug discovery for toxicity testing
Clay W. Scott et al.
TOXICOLOGY LETTERS (2013)
Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria
Derick Han et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips
Regis Baudoin et al.
XENOBIOTICA (2013)
A high content screening assay to predict human drug-induced liver injury during drug discovery
Mikael Persson et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2013)
Induced CYP3A4 Expression in Confluent Huh7 Hepatoma Cells as a Result of Decreased Cell Proliferation and Subsequent Pregnane X Receptor Activation
Louise Sivertsson et al.
MOLECULAR PHARMACOLOGY (2013)
Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
H. H. J. Gerets et al.
CELL BIOLOGY AND TOXICOLOGY (2012)
Feeder-Free and Serum-Free Production of Hepatocytes, Cholangiocytes, and Their Proliferating Progenitors from Human Pluripotent Stem Cells: Application to Liver-Specific Functional and Cytotoxic Assays
Naoko Nakamura et al.
CELLULAR REPROGRAMMING (2012)
In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs
Richard A. Thompson et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2012)
Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats
Imir G. Metushi et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2012)
Organotypic liver culture models: Meeting current challenges in toxicity testing
Edward L. LeCluyse et al.
CRITICAL REVIEWS IN TOXICOLOGY (2012)
Comparison of in vitro hepatogenic differentiation potential between various placenta-derived stem cells and other adult stem cells as an alternative source of functional hepatocytes
Hyun-Jung Lee et al.
DIFFERENTIATION (2012)
Role of immune reactions in drug-induced liver injury (DILI)
Cynthia Ju et al.
DRUG METABOLISM REVIEWS (2012)
Central role of mitochondria in drug-induced liver injury
Dominique Pessayre et al.
DRUG METABOLISM REVIEWS (2012)
In silico models for drug-induced liver injury - current status
Katarzyna R. Przybylak et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Effects of vitamin U (S-methyl methionine sulphonium chloride) on valproic acid induced liver injury in rats
Bahar Bilgin Sokmen et al.
FOOD AND CHEMICAL TOXICOLOGY (2012)
Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform
Sashi Nadanaciva et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2012)
In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI
Brett A. Howell et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2012)
Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4 alpha Transduction
Kazuo Takayama et al.
MOLECULAR THERAPY (2012)
Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha
Jingtao Lu et al.
TOXICOLOGICAL SCIENCES (2012)
Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria
Mathieu Porceddu et al.
TOXICOLOGICAL SCIENCES (2012)
Metabolic Activation and Inflammation Reactions Involved in Carbamazepine-Induced Liver Injury
Satonori Higuchi et al.
TOXICOLOGICAL SCIENCES (2012)
Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity
Mitchell R. McGill et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2012)
Optimization of the HepaRG cell model for drug metabolism and toxicity studies
Sebastien Antherieu et al.
TOXICOLOGY IN VITRO (2012)
Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury
Masakazu Kakuni et al.
TOXICOLOGY LETTERS (2012)
Endoplasmic Reticulum Stress Modulates Liver Inflammatory Immune Response in the Pathogenesis of Liver Ischemia and Reperfusion Injury
Jun Liu et al.
TRANSPLANTATION (2012)
Hepatic stellate cells require a stiff environment for myofibroblastic differentiation
Abby L. Olsen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional
Masami Hasegawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Development of a Whole-Cell Screening System for Evaluation of the Human CYP1A2-Mediated Metabolism
Chih-Chieh Chu et al.
BIOTECHNOLOGY AND BIOENGINEERING (2011)
An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
Ainhoa Ruiz-Aracama et al.
BMC GENOMICS (2011)
Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1
Jai-Hee Moon et al.
CELL RESEARCH (2011)
In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice
Hiroshi Yamazaki et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2011)
Case Definition and Phenotype Standardization in Drug-Induced Liver Injury
G. P. Aithal et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Drug Safety Sciences and the Bottleneck in Drug Development
P. B. Watkins
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
Lei Guo et al.
DRUG METABOLISM AND DISPOSITION (2011)
The protective effects of ursodeoxycholic acid on isoniazid plus rifampicin induced liver injury in mice
Xi Chen et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts
David Cotan et al.
FASEB JOURNAL (2011)
Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles
M. Isabel Lucena et al.
GASTROENTEROLOGY (2011)
A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease
Michael L. Washburn et al.
GASTROENTEROLOGY (2011)
Induction of Vesicular Steatosis by Amiodarone and Tetracycline Is Associated with Up-regulation of Lipogenic Genes in HepaRG Cells
Sebastien Antherieu et al.
HEPATOLOGY (2011)
Compromising Mitochondrial Function with the Antiretroviral Drug Efavirenz Induces Cell Survival-Promoting Autophagy
Nadezda Apostolova et al.
HEPATOLOGY (2011)
Diclofenac Inhibits Tumor Necrosis Factor-α-Induced Nuclear Factor-κB Activation Causing Synergistic Hepatocyte Apoptosis
Lisa Fredriksson et al.
HEPATOLOGY (2011)
Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines
Akemi Takata et al.
HEPATOLOGY INTERNATIONAL (2011)
Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver
Karima Begriche et al.
JOURNAL OF HEPATOLOGY (2011)
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
Pengyu Huang et al.
NATURE (2011)
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
Sayaka Sekiya et al.
NATURE (2011)
Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity
Reha Yildirimman et al.
TOXICOLOGICAL SCIENCES (2011)
Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes
M. G. L. Elferink et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2011)
A microfluidic hepatic coculture platform for cell-based drug metabolism studies
Eric Novik et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Pattern Recognition Receptors and Inflammation
Osamu Takeuchi et al.
CELL (2010)
Developing Structure-Activity Relationships for the Prediction of Hepatotoxicity
Nigel Greene et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2010)
Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction
Chin-Ju J. Hsiao et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Highly Efficient Generation of Human Hepatocyte-Like Cells from Induced Pluripotent Stem Cells
Karim Si-Tayeb et al.
HEPATOLOGY (2010)
Mitochondrial Superoxide Dismutase and Glutathione Peroxidase in Idiosyncratic Drug-Induced Liver Injury
M. Isabel Lucena et al.
HEPATOLOGY (2010)
The Role of Intestinal Endotoxin in Liver Injury: A Long and Evolving History
James P. Nolan
HEPATOLOGY (2010)
Drug-Induced Acute Liver Failure: Results of a U.S. Multicenter, Prospective Study
Adrian Reuben et al.
HEPATOLOGY (2010)
Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury
Peter T. Donaldson et al.
JOURNAL OF HEPATOLOGY (2010)
A Mouse Model of Severe Halothane Hepatitis Based on Human Risk Factors
Christine M. Dugan et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Identification of classifier genes for hepatotoxicity prediction in non steroidal anti inflammatory drugs
Hye Jin Cha et al.
MOLECULAR & CELLULAR TOXICOLOGY (2010)
Mitochondrial Rejuvenation After Induced Pluripotency
Steven T. Suhr et al.
PLoS One (2010)
The Bile Salt Export Pump: Clinical and Experimental Aspects of Genetic and Acquired Cholestatic Liver Disease
Ping Lam et al.
SEMINARS IN LIVER DISEASE (2010)
Contribution of High Basolateral Bile Salt Efflux to the Lack of Hepatotoxicity in Rat in Response to Drugs Inducing Cholestasis in Human
Katalin Jemnitz et al.
TOXICOLOGICAL SCIENCES (2010)
Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity
Patrick J. Shaw et al.
TOXICOLOGICAL SCIENCES (2010)
Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development
Ryan E. Morgan et al.
TOXICOLOGICAL SCIENCES (2010)
Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment
Wei Zou et al.
TOXICOLOGY (2010)
An Expert System Approach to the Assessment of Hepatotoxic Potential
Carol A. Marchant et al.
CHEMISTRY & BIODIVERSITY (2009)
A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding
Shintaro Nakayama et al.
DRUG METABOLISM AND DISPOSITION (2009)
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans
Alison H. Harrill et al.
GENOME RESEARCH (2009)
HLA-B☆5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
Ann K. Daly et al.
NATURE GENETICS (2009)
Drug-induced liver injury following positive drug rechallenge
Julie I. Papay et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2009)
Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen
Kazunori Fujimoto et al.
TOXICOLOGIC PATHOLOGY (2009)
Hepatotoxic Interaction of Sulindac with Lipopolysaccharide: Role of the Hemostatic System
Wei Zou et al.
TOXICOLOGICAL SCIENCES (2009)
Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity
Benjamin D. Cosgrove et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)
Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
Rohini Kashimshetty et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)
Drug-induced hepatotoxicity test using γ-glutamylcysteine synthetase knockdown rat
Mayu Morita et al.
TOXICOLOGY LETTERS (2009)
Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells
S. Choi et al.
XENOBIOTICA (2009)
Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice
Hiroshi Suemizu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies
Rozenn Josse et al.
DRUG METABOLISM AND DISPOSITION (2008)
Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies
Gilles Labbe et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2008)
In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone
James A. Dykens et al.
TOXICOLOGICAL SCIENCES (2008)
Cellular imaging predictions of clinical drug-induced liver injury
Jinghai J. Xu et al.
TOXICOLOGICAL SCIENCES (2008)
ACTOR - Aggregated Computational Toxicology Resource
Richard Judson et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis
A. Kindmark et al.
PHARMACOGENOMICS JOURNAL (2008)
Computational chemistry approach for the early detection of drug-induced idiosyncratic liver toxicity
Maykel Cruz-Monteagudo et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
Microscale culture of human liver cells for drug development
Salman R. Khetani et al.
NATURE BIOTECHNOLOGY (2008)
Precision-cut tissue slices as a tool to predict metabolism of novel drugs
Inge A. M. de Graaf et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2007)
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-Induced inflammatory liver injury
Francis F. Tukov et al.
TOXICOLOGICAL SCIENCES (2007)
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha
Patrick J. Shaw et al.
TOXICOLOGICAL SCIENCES (2007)
Knock down of γ-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity
Sho Akai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice
Hisaya Azuma et al.
NATURE BIOTECHNOLOGY (2007)
Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H:quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury
Yi-Shin Huang et al.
JOURNAL OF HEPATOLOGY (2007)
Circumventing the crabtree effect: Replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants
Lisa D. Marroquin et al.
TOXICOLOGICAL SCIENCES (2007)
Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
Michie M. K. Ong et al.
TOXICOLOGICAL SCIENCES (2007)
Mitochondrial abnonnalities - A link to idiosyncratic drug hepatotoxicity?
Urs A. Boelsterli et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2007)
Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
Nicola J. Hewitt et al.
DRUG METABOLISM REVIEWS (2007)
Role of neutrophils in a mouse model of halothane-induced liver injury
Qiang You et al.
HEPATOLOGY (2006)
Modest inflammation enhances diclofenac hepatotoxicity in rats: Role of neutrophils and bacterial translocation
Xiaomin Deng et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Drug-induced liver injury in a Swedish University hospital out-patient hepatology clinic
M. B. De Valle et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2006)
Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices
A. E. M. Vickers et al.
TOXICOLOGY IN VITRO (2006)
Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPARγ agonists on rat primary hepatocytes and human HepG2 cells
Lei Guo et al.
MOLECULAR DIVERSITY (2006)
Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating
L Richert et al.
DRUG METABOLISM AND DISPOSITION (2006)
Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils
JF Waring et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
The liver as an immunological organ
V Racanelli et al.
HEPATOLOGY (2006)
Development of a microscale cell culture analog to probe naphthalene toxicity
K Viravaidya et al.
BIOTECHNOLOGY PROGRESS (2004)
Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
JB Mills et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Near completely humanized liver in mice shows human-type metabolic responses to drugs
C Tateno et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
The lymphocyte transformation test in the diagnosis of drug hypersensitivity
WJ Pichler et al.
ALLERGY (2004)
The protective effect of taurine against cyclosporine A-induced oxidative stress and hepatotoxicity in rats
HH Hagar
TOXICOLOGY LETTERS (2004)
Acute and clinically relevant drug-induced liver injury:: a population based case-control study
FJ de Abajo et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Human and animal hepatocytes in vitro with extrapolation in vivo
PJ O'Brien et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2004)
Differentiation and isolation of hepatic-like cells from human embryonic stem cells
N Lavon et al.
DIFFERENTIATION (2004)
In silico models for the prediction of dose-dependent human hepatotoxicity
A Cheng et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2003)
Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats
JP Luyendyk et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse
T Moriguchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices
RJ Edwards et al.
DRUG METABOLISM AND DISPOSITION (2003)
Generation of hepatocyte-like cells from human embryonic stem cells
L Rambhatla et al.
CELL TRANSPLANTATION (2003)
Infection of a human hepatoma cell line by hepatitis B virus
P Gripon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Effects of troglitazone on HepG2 viability and mitochondrial function
MA Tirmenstein et al.
TOXICOLOGICAL SCIENCES (2002)
Incidence of drug-induced hepatic injuries: A French population-based study
C Sgro et al.
HEPATOLOGY (2002)
Underlying endotoxemia augments toxic responses to chlorpromazine: Is there a relationship to drug idiosyncrasy?
JP Buchweitz et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Enzyme-linked immunospot assays provide a sensitive tool for detection of cytokine secretion by monocytes
M Kouwenhoven et al.
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY (2001)
Hepatitis C virus replication in mice with chimeric human livers
DF Mercer et al.
NATURE MEDICINE (2001)
Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
M Dandri et al.
HEPATOLOGY (2001)
Co-amoxiclav jaundice: clinical and histological features and HLA class II association
J O'Donohue et al.
GUT (2000)
Comparative metabolism of carbon tetrachloride in rats, mice, and hamsters using gas uptake and PBPK modeling
KD Thrall et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A (2000)
Concordance of the toxicity of pharmaceuticals in humans and in animals
H Olson et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2000)
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