4.7 Review

Detailed resume of RNA m6A demethylases

期刊

ACTA PHARMACEUTICA SINICA B
卷 12, 期 5, 页码 2193-2205

出版社

INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2022.01.003

关键词

FTO; ALKBH5; RNA demethylation; Diseases; Inhibitors; Screening

资金

  1. National Key Research Program [2018YFE0195100]
  2. National Natural Science Foundation of China [82020108030, U21A20416, 82103997]
  3. Science and Technology Innovation Talents of Henan Provincial Education Department (China) [19IRTSTHN001]
  4. Basic and Frontier Technology Research Project of Henan Province (China) [212102310313]
  5. Basic Research of the Key Project of the High Education from the Education Department of Henan Province (China) [22ZX008]

向作者/读者索取更多资源

This review focuses on the studies of structure, inhibitors development, and biological function of FTO and ALKBH5.
N6-Methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, m6A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m6A demethylases have been reported, fat mass and obesity-associated protein (FTO) and alkylation protein AlkB homolog 5 (ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5. (c) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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