期刊
EBIOMEDICINE
卷 73, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2021.103655
关键词
Fish oil; Probiotics; Metabolomics; Gestational diabetes; Intervention
资金
- State Research Funding for university-level health research in the Turku University Hospital Expert Responsibility Area, Academy of Finland [258606]
- Diabetes Research Foundation
- Juho Vainio Foundation
- Janssen Research & Development, LLC
- Academy of Finland [295741]
- Academy of Finland (AKA) [295741, 295741] Funding Source: Academy of Finland (AKA)
The study found that fish oil and probiotics have an impact on the serum lipids of pregnant women with overweight or obesity, with the effect being influenced by the presence of GDM. The combination of fish oil and probiotics induced more changes in metabolites in women without GDM.
Background: If a pregnant woman is overweight, this can evoke metabolic alterations that may have health consequences for both mother and child. Methods: Pregnant women with overweight/obesity (n = 358) received fish oil+placebo, probiotics+placebo, fish oil+probiotics or placebo+placebo from early pregnancy onwards. The serum metabolome was analysed from fasting samples with a targeted NMR-approach in early and late pregnancy. GDM was diagnosed by OGTT. Findings: The intervention changed the metabolic profile of the women, but the effect was influenced by their GDM status. In women without GDM, the changes in nine lipids (FDR<0.05) in the fish oil+placebo-group differed when compared to the placebo+placebo-group. The combination of fish oil and probiotics induced changes in more metabolites, 46 of the lipid metabolites differed in women without GDM when compared to placebo+placebo-group; these included reduced increases in the concentrations and lipid constituents of VLDL-particles and less pronounced alterations in the ratios of various lipids in several lipoproteins. In women with GDM, no differences were detected in the changes of any metabolites due to any of the interventions when compared to the placebo+placebo-group (FDR<0.05). Interpretation: Fish oil and particularly the combination of fish oil and probiotics modified serum lipids in pregnant women with overweight or obesity, while no such effects were seen with probiotics alone. The effects were most evident in the lipid contents of VLDL and LDL only in women without GDM. (C) 2021 The Authors. Published by Elsevier B.V.
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