Host genetic factors determining COVID-19 susceptibility and severity

Article Andrology

Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients

Giulia Rastrelli et al.

Summary: In male patients with SARS-CoV-2 pneumonia, lower testosterone levels are associated with poor prognosis and mortality, indicating a potential role for testosterone in determining clinical outcomes in COVID-19 patients.

ANDROLOGY (2021)

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Article Biochemistry & Molecular Biology

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Jin Wei et al.

Summary: Identification of essential host genes for SARS-CoV-2 infection, including ACE2 and Cathepsin L, and the discovery of pro-viral genes and pathways specific to SARS lineage and pan-coronavirus provide potential therapeutic targets and insights into pathogenesis of COVID-19. Small-molecule antagonists of these gene products inhibited SARS-CoV-2 infection across species, highlighting their conserved role in susceptibility to highly pathogenic CoVs.

CELL (2021)

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Article Immunology

Associations Between Genetically Predicted Protein Levels and COVID-19 Severity

Jingjing Zhu et al.

Summary: By genetically predicting protein levels, we identified 18 candidate proteins associated with COVID-19 severity, with 12 maintaining associations even after corrections.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Letter Dermatology

Androgen receptor genetic variant predicts COVID-19 disease severity: a prospective longitudinal study of hospitalized COVID-19 male patients

J. Mccoy et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Cell Biology

The Impact of COVID-19 Disease on Platelets and Coagulation

Geoffrey D. Wool et al.

Summary: COVID-19 infection can lead to a proinflammatory state and abnormalities in the coagulation mechanism, with patients often experiencing thrombosis. Elevated levels of D-dimer are positively correlated with mortality, and patients typically exhibit mild thrombocytopenia.

PATHOBIOLOGY (2021)

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Article Genetics & Heredity

Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19

Hannes Vietzen et al.

Summary: Host genetic variants, particularly KLRC2 deletion and HLA-E*0101, are significantly overrepresented in hospitalized COVID-19 patients, especially those requiring intensive care. These genetic variants are independent risk factors for severe COVID-19.

GENETICS IN MEDICINE (2021)

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Article Multidisciplinary Sciences

Genetic mechanisms of critical illness in COVID-19

Erola Pairo-Castineira et al.

Summary: In critically ill patients with COVID-19, host genetic variants associated with antiviral defense mechanisms and inflammatory organ damage were identified through a genome-wide association study. These genetic signals provide potential targets for therapeutic development and repurposing of existing drugs. Large-scale randomized clinical trials will be essential to confirm the effectiveness of targeted treatment strategies.

NATURE (2021)

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Article Medicine, General & Internal

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

A. C. Kalil et al.

Summary: Combination treatment with baricitinib plus remdesivir was superior to remdesivir alone in reducing recovery time and accelerating improvement in clinical status among patients with Covid-19, notably among those receiving high-flow oxygen or noninvasive ventilation. The combination was associated with fewer serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Cell Biology

Genetic and epigenetic factors associated with increased severity of Covid-19

Zafer Yildirim et al.

Summary: The severity of Covid-19 disease is associated with host genetic and epigenetic factors, including genetic variants related to the SARS-CoV-2 entry mechanism and host innate immune response genes, as well as ABO, 3p21.31, and 9q34.2 loci. Enhanced understanding of these factors and viral interactions is critical for better prognostic tools and innovative therapeutics.

CELL BIOLOGY INTERNATIONAL (2021)

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Review Virology

Role of Toll-like receptors in the pathogenesis of COVID-19

Shaghayegh Khanmohammadi et al.

Summary: COVID-19 caused by SARS-CoV-2 has led to a pandemic. TLRs play a crucial role in activating the immune system in response to the virus, and could potentially be a target for controlling the infection. Understanding the mechanisms of TLR in COVID-19 may help in developing vaccines and treatments.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Biochemistry & Molecular Biology

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

Sirui Zhou et al.

Summary: The study identified that increased levels of OAS1 protein are associated with reduced susceptibility and severity of COVID-19, providing evidence for a protective role of OAS1 in adverse outcomes. This suggests that pharmacological agents that increase OAS1 levels could be prioritized for drug development against COVID-19. The variant of the OAS1 gene associated with decreased risk of death in COVID-19 patients encodes an enzyme critical for the innate immune response to viral infections.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Anthony C. Gordon et al.

Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

A genomic region associated with protection against severe COVID-19 is inherited from Neandertals

Hugo Zeberg et al.

Summary: Recent studies have identified a genetic risk factor for severe illness with COVID-19 inherited from Neandertals, but also a protective Neandertal haplotype. These genetic factors influence the need for intensive care after infection and are present in populations worldwide outside of Africa.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

Fei Li et al.

Summary: Enzalutamide effectively inhibited SARS-CoV-2 infection in human prostate cells, however, such antiviral efficacy was lacking in human lung cells and organoids.

NATURE COMMUNICATIONS (2021)

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Article Biology

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

Chiara Fallerini et al.

Summary: Loss-of-function variants in TLR7 were found to be associated with severe COVID-19 in young males, representing a subset of male patients and contributing to disease susceptibility in approximately 2% of severe COVID-19 cases. This study provides insight into the genetic factors influencing COVID-19 severity in male patients.

ELIFE (2021)

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Article Medicine, General & Internal

Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

Margherita Baldassarri et al.

Summary: The study found that men with long AR polyQ repeats are more likely to develop severe disease in COVID-19, and they may have higher testosterone levels. However, carriers of long polyQ alleles have lower testosterone levels, which may predict a need for more intensive care.

EBIOMEDICINE (2021)

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Article Multidisciplinary Sciences

Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

Qu Deng et al.

Summary: The study suggests a potential role of androgen in SARS-CoV-2 infection by regulating ACE2 and TMPRSS2 transcription. Camostat, a TMPRSS2 inhibitor, blocks the cleavage of SARS-CoV-2 Spike protein, providing evidence of TMPRSS2's direct role in viral fusion to host cells. Androgen-deprivation, anti-androgens, or camostat attenuate SARS-CoV-2 cellular entry, highlighting the importance of TMPRSS2 inhibitors and androgen-deprivation therapy in preventing COVID-19 progression.

ISCIENCE (2021)

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Letter Cardiac & Cardiovascular Systems

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Yuyang Lei et al.

CIRCULATION RESEARCH (2021)

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Article Medicine, General & Internal

The MUC5B Promoter Polymorphism Associates With Severe COVID-19 in the European Population

Coline H. M. van Moorsel et al.

Summary: This study found that carriage of the T-allele of MUC5B rs35705950 provides protection against severe COVID-19, providing further evidence for trade-offs between optimal mucin expression levels in the aging lung.

FRONTIERS IN MEDICINE (2021)

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Article Medicine, General & Internal

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani et al.

LANCET (2021)

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Article Genetics & Heredity

Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity

Janie F. Shelton et al.

Summary: A study of over one million 23andMe research participants identified genetic and nongenetic associations with COVID-19 susceptibility and severity. The research found a strong association between blood type, a gene-rich locus on chromosome 3p21.31, and COVID-19 diagnosis and outcome severity.

NATURE GENETICS (2021)

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Article Biochemistry & Molecular Biology

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Liam Gaziano et al.

Summary: Large-scale Mendelian randomization and colocalization analyses using gene expression and soluble protein data identified IFNAR2 and ACE2 as promising therapeutic targets for early management of COVID-19. Repurposing drugs offers a rapid solution to address the urgent need for therapeutic interventions against COVID-19.

NATURE MEDICINE (2021)

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Article Genetics & Heredity

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

Liuyang Wang et al.

Summary: The study utilized cross-phenotype associations to identify shared genetic architecture among human diseases, leading to insights on pathophysiology and novel hypotheses generation. The interactive web database created facilitated exploration and rapid analysis of GWAS data, revealing unexpected overlaps between COVID-19 and other diseases, potentially uncovering new therapeutic targets.

GENOME MEDICINE (2021)

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Article Critical Care Medicine

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

Sanjay Ramakrishnan et al.

Summary: The study found that early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and accelerated recovery time in patients with early COVID-19.

LANCET RESPIRATORY MEDICINE (2021)

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Article Multidisciplinary Sciences

Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19

Immacolata Andolfo et al.

Summary: The study conducted an in-depth genetic analysis of COVID-19, revealing five single nucleotide polymorphisms on chromosome 21 associated with severe cases. The minor alleles of these SNPs were found to be correlated with a reduced risk of developing severe COVID-19 and higher expression levels of MX1 in blood. These findings suggest that host genetic factors may influence the clinical presentations of COVID-19 and highlight MX1 as a potential therapeutic target.

ISCIENCE (2021)

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Review Biochemistry & Molecular Biology

Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs

Sebastien Boutin et al.

Summary: SARS-CoV-2 is the virus causing the major pandemic today, primarily causing lung infection but impacting the body systemically, with fatal outcomes linked to specific host factors and co-morbidities. The virus spreads quickly, affecting individuals of all ages, ethnicities, and gender, with changes in the microbiome believed to play a role in infection acquisition and disease progression.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Article Medical Laboratory Technology

ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors

Jaroslav A. Hubacek et al.

Summary: This study found that ACE I/D polymorphism has the potential to predict the severity of COVID-19, with I/I homozygotes being at increased risk of symptomatic COVID-19.

CLINICA CHIMICA ACTA (2021)

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Article Genetics & Heredity

Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation

Yulin Dai et al.

Summary: COVID-19 primarily affects the respiratory system and severe symptoms may be associated with genetic variations. Studies have shown that the genes CXCR6 and CCR9 play a regulatory role in lung gene expression and are related to disease severity.

HUMAN GENETICS (2021)

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Review Infectious Diseases

Variants in ACE2; potential influences on virus infection and COVID-19 severity

Behnaz Bakhshandeh et al.

Summary: The COVID-19 disease, caused by severe acute respiratory syndrome coronavirus-2 (SARSCoV-2), exhibits clinical variability due to factors such as age, sex, genetic variations, and lifestyle. Variants in the ACE2 gene may play a crucial role in determining susceptibility to the disease.

INFECTION GENETICS AND EVOLUTION (2021)

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Article Virology

The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner

Victoria Callahan et al.

Summary: The study shows that SARS-CoV-2 infection induces an inflammatory state in human lung epithelial cells with elevated levels of pro-inflammatory chemokines and cytokines. Inhibition of the AKT pathway may reduce the induction of these chemokines, potentially providing specific targets for mitigating SARS-CoV-2 pathogenesis associated with hyperinflammation.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences

Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes

Mehdi Baratchian et al.

Summary: Sex discordance in COVID-19 outcomes may not be related to TMPRSS2 but may be associated with modest changes in ACE2.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Multidisciplinary

CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2

Razie Amraei et al.

Summary: The study identified CD209L and CD209 as receptors for SARS-CoV-2 entry into human cells. CD209L is prominently expressed in lung and kidney tissues and interacts with ACE2, potentially playing a role in SARS-CoV-2 infection. This finding may have implications for antiviral drug development in tissues where ACE2 expression is low or absent.

ACS CENTRAL SCIENCE (2021)

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Letter Immunology

Multisystem Inflammatory Syndrome in Adults after Mild SARS-CoV-2 Infection, Japan

Yasuhiro Yamada et al.

Summary: This case describes a 51-year-old man in Japan with minimally symptomatic SARS-CoV-2 infection, who later developed multisystem inflammatory syndrome. Characteristics included severe inflammation, cardiac dysfunction, and IgG positivity. Clinicians should pay attention to detailed patient history and examine IgG levels in cases of inflammatory disease with unexplained cardiac decompensation.

EMERGING INFECTIOUS DISEASES (2021)

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Article Medicine, Research & Experimental

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19

Gundula Povysil et al.

Summary: The study found no evidence of association between rare pLOF variants in 13 candidate genes and severe COVID-19 outcomes. Only one rare pLOF mutation was identified across these genes among cases with severe COVID-19, and there was no enrichment of pLOFs in severe cases compared to controls or mild COVID-19 cases.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

Genetic risk for severe COVID-19 correlates with lower inflammatory marker levels in a SARS-CoV-2-negative cohort

Timothy R. Powell et al.

Summary: This study examined how genetic risk for severe COVID-19 correlated with baseline levels of inflammatory markers in a SARS-CoV-2-negative population cohort. Higher genetic risk was associated with lower levels of certain inflammatory markers, with profiles diverging further from the norm with age and obesity. The results suggest that individuals at risk of severe COVID-19 may have deficient innate immunity marked by reduced levels of certain inflammatory markers at baseline.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

The signal pathways and treatment of cytokine storm in COVID-19

Lan Yang et al.

Summary: The COVID-19 pandemic is a global crisis with devastating effects, where immunopathology plays a crucial role in disease progression, particularly the cytokine storm which has a significant impact on prognosis. Understanding and targeting the pathways involved in cytokine storm could lead to more effective treatment strategies for COVID-19.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Public, Environmental & Occupational Health

Development and validation of a clinical and genetic model for predicting risk of severe COVID-19

Gillian S. Dite et al.

Summary: The study developed and validated a clinical and genetic model to predict the risk of severe COVID-19 using UK Biobank data. The new model showed association with severe COVID-19 and acceptable discrimination in the validation dataset, suggesting it can accurately predict individual risk, especially in regions with limited vaccine availability.

EPIDEMIOLOGY AND INFECTION (2021)

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Letter Biochemistry & Molecular Biology

Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19

Yao Yao et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Immunology

Circulating Levels of Interleukin-6 and Interleukin-10, But Not Tumor Necrosis Factor-Alpha, as Potential Biomarkers of Severity and Mortality for COVID-19: Systematic Review with Meta-analysis

Wanvisa Udomsinprasert et al.

Summary: The levels of IL-6 and IL-10 in COVID-19 patients may serve as potential biomarkers for disease severity and mortality.

JOURNAL OF CLINICAL IMMUNOLOGY (2021)

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Article Critical Care Medicine

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Richard J. Allen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Editorial Material Medicine, General & Internal

A novel coronavirus outbreak of global health concern

Chen Wang et al.

LANCET (2020)

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Editorial Material Public, Environmental & Occupational Health

The COVID-19 epidemic

Thirumalaisamy P. Velavan et al.

TROPICAL MEDICINE & INTERNATIONAL HEALTH (2020)

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Article Oncology

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N=4532)

M. Montopoli et al.

ANNALS OF ONCOLOGY (2020)

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Article Medicine, General & Internal

Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank

Claire L. Niedzwiedz et al.

BMC MEDICINE (2020)

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Letter Hematology

COVID-19 and ABO blood group: another viewpoint

Christiane Gerard et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Article Immunology

Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19

Hin Chu et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Editorial Material Cardiac & Cardiovascular Systems

ABO blood group predisposes to COVID-19 severity and cardiovascular diseases

Xiaofeng Dai

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

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Article Virology

Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2

Austin Nguyen et al.

JOURNAL OF VIROLOGY (2020)

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Review Critical Care Medicine

Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations

Jason Phua et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Public, Environmental & Occupational Health

Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019-COVID-NET, 14 States, March 1-30, 2020

Shikha Garg et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

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Article Cell Biology

Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease-2019 (COVID-19)

Wei Wang et al.

HLA (2020)

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Article Biochemistry & Molecular Biology

Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes

Monojit Debnath et al.

FASEB JOURNAL (2020)

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Article Microbiology

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

Nan Wang et al.

CELL HOST & MICROBE (2020)

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Article Medicine, General & Internal

Presence of Genetic Variants Among Young Men With Severe COVID-19

Caspar I. van der Made et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Editorial Material Medicine, General & Internal

Anti-IL-6 receptor antibody treatment for severe COVID-19 and the potential implication of IL-6 gene polymorphisms in novel coronavirus pneumonia

Zulvikar Syambani Ulhaq et al.

MEDICINA CLINICA (2020)

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Article Medicine, General & Internal

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

David Ellinghaus et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jerome Hadjadj et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

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Article Critical Care Medicine

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19 a prospective observational study

Pratik Sinha et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 Infection Boosts MX1 Antiviral Effector in COVID-19 Patients

Juan Bizzotto et al.

ISCIENCE (2020)

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Article Genetics & Heredity

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome

Juan Gomez et al.

GENE (2020)

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Review Medicine, General & Internal

Cytokine Storm

David C. Fajgenbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

Philip A. Mudd et al.

SCIENCE ADVANCES (2020)

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Article Cell Biology

Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility

Fang Wang et al.

CELL DISCOVERY (2020)

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Article Immunology

CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

Alexander N. Wein et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Review Rheumatology

Interleukin-4 cytokine single nucleotide polymorphisms in kawasaki disease: a case-control study and a review of knowledge

Raheleh Assari et al.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2018)

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Article Critical Care Medicine

Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome

Yaseen M. Arabi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Article Evolutionary Biology

Origin and development of oligoadenylate synthetase immune system

Jiaxiang Hu et al.

BMC EVOLUTIONARY BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

Franklin L. Zhong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Respiratory System

Genome-wide association study of subclinical interstitial lung disease in MESA

Ani Manichaikul et al.

RESPIRATORY RESEARCH (2017)

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Article Cell Biology

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Calliope A. Dendrou et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis

Hui Zhang et al.

FEBS JOURNAL (2015)

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Article Multidisciplinary Sciences

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits

Dorothee Diogo et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Kristin G. Ardlie et al.

SCIENCE (2015)

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Article Biochemistry & Molecular Biology

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors

Raphael N. Vuille-dit-Bille et al.

AMINO ACIDS (2015)

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Article Multidisciplinary Sciences

The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis

Inga Patarcic et al.

SCIENTIFIC REPORTS (2015)

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Article Developmental Biology

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2

Shanru Li et al.

DEVELOPMENT (2012)

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Article Multidisciplinary Sciences

Foxp4 Is Dispensable for T Cell Development, but Required for Robust Recall Responses

Karla R. Wiehagen et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Association between CD209-336A/G and-871A/G Polymorphisms and Susceptibility of Tuberculosis: A Meta-Analysis

Kai Chang et al.

PLOS ONE (2012)

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Article Immunology

CD209 (DC-SIGN)-336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese

Kelvin Yuen Kwong Chan et al.

HUMAN IMMUNOLOGY (2010)

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Article Immunology

Significance of the Myxovirus Resistance A (MxA) Gene-123C>A Single-Nucleotide Polymorphism in Suppressed Interferon β Induction of Severe Acute Respiratory Syndrome Coronavirus Infection

Johannes Chi-Yun Ching et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

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Article Biochemistry & Molecular Biology

The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition

Jamie R. Flammer et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

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Article Biochemistry & Molecular Biology

The Cytoplasmic Peptidase DPP9 Is Rate-limiting for Degradation of Proline-containing Peptides

Ruth Geiss-Friedlander et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Biochemistry & Molecular Biology

Glucocorticoids inhibit IRF3 phosphorylation in response to toll-like receptor-3 and-4 by targeting TBK1 activation

Claire E. McCoy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Infectious Diseases

Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study

Jing He et al.

BMC INFECTIOUS DISEASES (2006)

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Article Virology

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