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Novel targets, treatments, and advanced models for intracerebral haemorrhage

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Article Biochemistry & Molecular Biology

MEC17-induced α-tubulin acetylation restores mitochondrial transport function and alleviates axonal injury after intracerebral hemorrhage in mice

Yang Yang et al.

Summary: This study identified the molecular mechanisms driving axonal degeneration after ICH and demonstrated that enhancing microtubule acetylation and inhibiting mitochondrial permeability transition pore opening can synergistically protect corticospinal tract integrity and promote fine motor control recovery.

JOURNAL OF NEUROCHEMISTRY (2022)

Article Endocrinology & Metabolism

HDAC inhibition reduces white matter injury after intracerebral hemorrhage

Heng Yang et al.

Summary: Inhibition of HDACs can reduce neuroinflammation and white matter damage after ICH by modulating microglia/macrophage polarization, leading to improved neurological functional recovery.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Article Biochemistry & Molecular Biology

Circulating tRNA Fragments as a Novel Biomarker Class to Distinguish Acute Stroke Subtypes

T. Truc My Nguyen et al.

Summary: This study found that tRNA-derived fragments can serve as promising novel biomarkers to distinguish between acute IS, ICH, SM, and healthy controls.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Neurosciences

MicroNAR-194-5p hinders the activation of NLRP3 inflammasomes and alleviates neuroinflammation during intracerebral hemorrhage by blocking the interaction between TRAF6 and NLRP3

Sai-ying Wan et al.

Summary: The study investigated the role of miR-194-5p in intracerebral hemorrhage (ICH) and found that overexpression of miR-194-5p reduced neuropathological injury and inhibited NLRP3-mediated inflammatory injury. miR-194-5p targeted TRAF6, which interacted with NLRP3 to promote the activation of NLRP3 inflammasomes. Overexpression of miR-194-5p reduced the TRAF6/NLRP3 interaction, thereby alleviating neuroinflammation.

BRAIN RESEARCH (2021)

Article Clinical Neurology

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Valery L. Feigin et al.

Summary: Regularly updated data on stroke including incidence, prevalence, mortality, disability, risk factors, and trends are crucial for evidence-based care planning. The Global Burden of Diseases Study provides comprehensive measurement of these metrics. From 1990 to 2019, while age-standardized rates improved, the number of strokes and deaths increased. Low-income countries had the highest stroke-related mortality and DALY rates, with high body-mass index being the fastest-growing risk factor.

LANCET NEUROLOGY (2021)

Article Biochemistry & Molecular Biology

Type-I diabetes aggravates post-hemorrhagic stroke cognitive impairment by augmenting oxidative stress and neuroinflammation in mice

Ghaith A. Bahader et al.

Summary: The study demonstrates that diabetes mellitus exacerbates the outcomes of hemorrhagic stroke, including increased hematoma volume and deficits in post-stroke locomotor, sensorimotor, and cognitive behavior. This research contributes to a better understanding of the impact of diabetes comorbidity on hemorrhagic stroke outcomes and reveals the important pathological mechanisms underlying diabetes-induced exacerbation of ICH injury.

NEUROCHEMISTRY INTERNATIONAL (2021)

Article Critical Care Medicine

Early alterations in heart rate are associated with poor outcome in patients with intracerebral hemorrhage

Verena Rass et al.

Summary: The study identified that factors such as intraventricular hemorrhage, prolonged QRS complex, and female sex were associated with higher heart rate variability in the acute phase after spontaneous intracerebral hemorrhage (ICH). A higher heart rate variability in the acute phase was found to be related to poor 3-month outcome in ICH patients.

JOURNAL OF CRITICAL CARE (2021)

Article Immunology

The Changes of Leukocytes in Brain and Blood After Intracerebral Hemorrhage

Shuhao Mei et al.

Summary: In intracerebral hemorrhage (ICH), inflammation plays a critical role in brain injury. Immune cells, such as natural killer cells and monocytes, infiltrate the brain parenchyma and contribute to injury through degranulation, phagocytosis, and cytokine secretion. Non-classical monocytes show enhanced heme metabolism, wound healing, and antigen processing during the subacute phase of ICH. The study highlights the importance of infiltrating immune cells in ICH and suggests potential therapeutic targets.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Inhibition of exosome release augments neuroinflammation following intracerebral hemorrhage

Minshu Li et al.

Summary: Inhibition of exosome release exacerbates neuroinflammation and ICH injury by increasing leukocyte infiltration into the brain and barrier disruption. However, exosomes extracted from the ICH brain can reduce ICH injury in recipient mice, showing potential neuroprotective effects. Further investigation into the impact of exosomes released from the ICH brain on the immune system is warranted.

FASEB JOURNAL (2021)

Review Biochemistry & Molecular Biology

Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy

Yasuteru Inoue et al.

Summary: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid beta (Aβ) in brain vessels, leading to vessel fragility, hemorrhages, and neurological symptoms. The pathogenesis of CAA is not fully understood, but recent advances in mass spectrometric methodology have identified potential key molecules associated with CAA. Understanding the interactions between cerebrovascular Aβ deposits and these molecules may lead to the development of effective CAA therapeutics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Microbiology

Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice

Xiaobo Yu et al.

Summary: Intracerebral hemorrhage (ICH) can disrupt gut microbiota balance, leading to changes in immune responses and neuroinflammation. Restoring a healthy microbiota can alleviate functional deficits and neuroinflammation after ICH.

FRONTIERS IN MICROBIOLOGY (2021)

Article Medicine, Research & Experimental

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

Brittany A. Goods et al.

Summary: This study focused on intracerebral hemorrhage (ICH) in a patient, revealing the importance of inflammation in brain tissue injury and demonstrating dynamic changes in leukocyte responses over time using single-cell RNA-Seq. The findings suggest that sensitive methods such as scRNA-Seq could provide greater understanding of complex intracerebral events.

JCI INSIGHT (2021)

Article Medicine, General & Internal

Potential Genes and Mechanisms Linking Intracerebral Hemorrhage and Depression: A Bioinformatics-Based Study

Cuihua Zou et al.

Summary: This study investigated the potential pathogenic mechanisms of post-intracerebral hemorrhage depression by analyzing DEGs, conducting enrichment analysis, interaction analysis, and integrated bridge landscape analysis. Potential hub bridge genes and pathways related to post-ICH depression were identified, suggesting references for further research on the pathogenesis of post-ICH depression.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

Article Neurosciences

Metoprolol attenuates intracerebral hemorrhage-induced cardiac damage by suppression of sympathetic overactivity in mice

Liqun Zhang et al.

Summary: This study found that sympathetic overactivity induced by ICH may play a significant role in post-ICH cardiac dysfunction by mediating inflammatory response. Treating ICH mice with metoprolol to suppress sympathetic overactivity improved cardiac and neurological function.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2021)

Article Multidisciplinary Sciences

Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats

Tiffany F. C. Kung et al.

Summary: The study found that the sulfonylurea 1 transient receptor potential melastatin 4 (Sur1-Trpm4) channel blocker glibenclamide did not have favorable effects on edema, ionic dyshomeostasis, and functional impairment under severe intracerebral hemorrhage conditions.

PLOS ONE (2021)

Article Clinical Neurology

Role of Complement Component 3 in Early Erythrolysis in the Hematoma After Experimental Intracerebral Hemorrhage

Ming Wang et al.

Summary: This study demonstrated that C3-deficient mice had less severe erythrolysis and brain injury following ICH compared with C3-sufficient mice. The release of Prx2 after erythrolysis was found to cause brain damage and neuroinflammation in mice.

STROKE (2021)

Article Neurosciences

Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion

Peijun Jia et al.

Summary: This study aimed to compare two commonly used murine ICH models (c-ICH and b-ICH) and found that BBB disruption occurred earlier and more pronounced in the c-ICH model compared to the b-ICH model.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Review Clinical Neurology

Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage

Xiaoyu Shi et al.

Summary: This review summarizes various protocols that have been applied to assess neurologic function outcomes in rodent ICH models, including pain, motor, cognition, and emotion tests.

FRONTIERS IN NEUROLOGY (2021)

Review Clinical Neurology

White Matter Injury After Intracerebral Hemorrhage

Xiongjie Fu et al.

Summary: Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity, mortality, and disability rates. Research indicates that the development of white matter injury (WMI) following ICH is complex and determines the prognosis of patients. Comprehensive treatment and understanding the relationship between WMI and other brain cells may reveal therapeutic targets for ICH.

FRONTIERS IN NEUROLOGY (2021)

Article Cell Biology

Exosomes From miR-19b-3p-Modified ADSCs Inhibit Ferroptosis in Intracerebral Hemorrhage Mice

Xia Yi et al.

Summary: Exosomes from miR-19b-3p-modified ADSCs are able to inhibit ferroptosis and improve ICH damage when administered to ICH mice or cultured neurons.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Peripheral Vascular Disease

Intracerebral Hemorrhage Recurrence in Patients with and without Cerebral Amyloid Angiopathy

Joao Pinho et al.

Summary: This study confirms a higher risk of ICH recurrence in patients with CAA-related ICH and suggests that age, disseminated cSS, and burden of EPVS in the centrum semiovale are associated with ICH recurrence.

CEREBROVASCULAR DISEASES EXTRA (2021)

Article Clinical Neurology

European Stroke Organisation (ESO) guidelines on blood pressure management in acute ischaemic stroke and intracerebral haemorrhage

Else Charlotte Sandset et al.

Summary: The optimal blood pressure management in acute ischaemic stroke and acute intracerebral haemorrhage remains controversial, and the ESO guidelines offer evidence-based recommendations. Expert consensus statements provide additional guidance in cases where there is insufficient evidence to make recommendations.

EUROPEAN STROKE JOURNAL (2021)

Article Chemistry, Multidisciplinary

Nanoparticles improved resveratrol brain delivery and its therapeutic efficacy against intracerebral hemorrhage

Yousheng Mo et al.

Summary: Intracerebral hemorrhage (ICH) is a neurological disorder caused by nontraumatic rupture of blood vessels in the brain, while ferroptosis is an important pathological feature. Resveratrol (Res) has neuroprotective effects but limited oral bioavailability. Using polymer nanoparticles (NPs) to encapsulate Res can improve its bioavailability and accumulation in the brain.

NANOSCALE (2021)

Article Endocrinology & Metabolism

MicroRNA and their target mRNAs change expression in whole blood of patients after intracerebral hemorrhage

Xiyuan Cheng et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

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Novel Chronic Mouse Model of Cerebral Cavernous Malformations

Cecile Cardoso et al.

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Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets

Christine Tschoe et al.

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IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

Jing Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Ishraq Alim et al.

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Lipid levels and the risk of hemorrhagic stroke among women

Pamela M. Rist et al.

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Safety of oral anticoagulants on experimental brain microbleeding and cognition

Maud Petrault et al.

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Secondary Bleeding During Acute Experimental Intracerebral Hemorrhage

Frieder Schlunk et al.

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Minocycline reduces intracerebral hemorrhage-induced white matter injury in piglets

Heng Yang et al.

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miR-195 Has a Potential to Treat Ischemic and Hemorrhagic Stroke through Neurovascular Protection and Neurogenesis

Hsin-Yun Cheng et al.

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Brain endothelial cell junctions after cerebral hemorrhage: Changes, mechanisms and therapeutic targets

Richard F. Keep et al.

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Role of Exosomes Derived from miR-133b Modified MSCs in an Experimental Rat Model of Intracerebral Hemorrhage

Haitao Shen et al.

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Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

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Behavioral outcome measures to improve experimental stroke research

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Behavioral Effect of Short- and Long-Term Exercise on Motor Functional Recovery after Intracerebral Hemorrhage in Rats

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Mechanisms and Therapeutic Targets of Depression After Intracerebral Hemorrhage

Yinan Wu et al.

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Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension

Anja Meissner et al.

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M2 Monocyte Microparticles Are Increased in Intracerebral Hemorrhage

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Blood microRNAs as potential diagnostic markers for hemorrhagic stroke

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Idarucizumab Improves Outcome in Murine Brain Hemorrhage Related to Dabigatran

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