期刊
EBIOMEDICINE
卷 75, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2021.103783
关键词
Ascending aorta size; Ascending aorta distensibility; Artificial intelligence; Cardiovascular disease; Genome-wide association study; Mendelian randomization study
资金
- Center for Information Technology of the University of Groningen
In this study, an AI-based analysis pipeline was used to investigate the genetic factors associated with the size and function of the ascending aorta (AAo). The results showed that 78 loci were causally associated with aortic aneurysm development, but not with other vascular diseases.
Background Alterations in the anatomic and biomechanical properties of the ascending aorta (AAo) can give rise to various vascular pathologies. The aim of the current study is to gain additional insights in the biology of the AAo size and function. Methods We developed an AI based analysis pipeline for the segmentation of the AAo, and the extraction of AAO parameters. We then performed genome-wide association studies of AAo maximum area, AAo minimum area and AAo distensibility in up to 37,910 individuals from the UK Biobank. Variants that were significantly associated with AAo phenotypes were used as instrumental variables in Mendelian randomization analyses to investigate potential causal relationships with coronary artery disease, myocardial infarction, stroke and aneurysms. Findings Genome-wide association studies revealed a total of 107 SNPs in 78 loci. We annotated 101 candidate genes involved in various biological processes, including connective tissue development (THSD4 and COL6A3). Mendelian randomization analyses showed a causal association with aneurysm development, but not with other vascular diseases. Interpretation We identified 78 loci that provide insights into mechanisms underlying AAo size and function in the general population and provide genetic evidence for their role in aortic aneurysm development. Copyright (C) 2021 The Author(s). Published by Elsevier B.V.
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