期刊
SCIENCE ADVANCES
卷 7, 期 45, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abk3259
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资金
- BMBF [05 K2018]
- Behorde fur Wissenschaft, Forschung und Gleichstellung of the city of Hamburg
The uptake of peptides in mammals is crucial for nutrition and inflammatory diseases, which is mediated by transporters in solute carrier family 15. The structures of human PepT1 and PepT2 captured in different states provide insights into substrate recognition and conformational transitions during transport, supporting future drug design efforts to enhance bioavailability in the human body.
The uptake of peptides in mammals plays a crucial role in nutrition and inflammatory diseases. This process is mediated by promiscuous transporters of the solute carrier family 15, which form part of the major facilitator superfamily. Besides the uptake of short peptides, peptide transporter 1 (PepT1) is a highly abundant drug transporter in the intestine and represents a major route for oral drug delivery. PepT2 also allows renal drug reabsorption from ultrafiltration and brain-to-blood efflux of neurotoxic compounds. Here, we present cryogenic electron microscopy (cryo-EM) structures of human PepT1 and PepT2 captured in four different states throughout the transport cycle. The structures reveal the architecture of human peptide transporters and provide mechanistic insights into substrate recognition and conformational transitions during transport. This may support future drug design efforts to increase the bioavailability of different drugs in the human body.
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