期刊
SCIENCE ADVANCES
卷 7, 期 46, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abk1210
关键词
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资金
- National Natural Science Foundation of China [81971744, U1932107, 91859101, 82001952]
- National Natural Science Foundation of Tianjin [19JCZDJC34000, 20JCYBJC00940]
- Independent Innovation Foundation of Tianjin University
- National Institutes of Health [NS092868, AG059694]
Artificial enzymes have potential in disease diagnosis and biotechnology due to their high stability, easy synthesis, and cost-effectiveness. The oligomeric nanozyme (O-NZ) showed ultrafast electron transfer and achieved ultrahigh catalytic activity, addressing the limitations of catalytic rate in artificial enzymes.
Artificial enzymes have attracted wide interest in disease diagnosis and biotechnology due to high stability, easy synthesis, and cost effectiveness. Unfortunately, their catalytic rate is limited to surface electron transfer, affecting the catalytic and biological activity. Here, we report an oligomeric nanozyme (O-NZ) with ultrafast electron transfer, achieving ultrahigh catalytic activity. O-NZ shows electron transfer of 1.8 nanoseconds in internal cores and 1.2 picoseconds between core and ligand molecule, leading to ultrahigh superoxidase dismutase-like and glutathione peroxidase-like activity (comparable with natural enzyme, Michaelis constant = 0.87 millimolars). Excitingly, O-NZ can improve the 1-month survival rate of mice with acute brain trauma from 50 to 90% and promote the recovery of long-term neurocognition. Biochemical experiments show that O-NZ can decrease harmful peroxide and superoxide via in vivo catalytic chain reaction and reduce acute neuroinflammation via nuclear factor erythroid-2 related factor 2-mediated up-regulation of heme oxygenase-1 expression.
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