期刊
SCIENCE ADVANCES
卷 8, 期 2, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abl8812
关键词
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资金
- NIH-National Institute on Deafness and Other Communication Disorders [NIHDC016644]
- Department of the Navy, Office of Naval Research under ONR [N00014-20-1-2418]
- NSF MRSEC program [DMR-1719875]
A zwitterionic polymer was designed and synthesized to achieve contact deactivation of coronavirus in dry ambient conditions and reduce virus adhesion and bacterial biofilm formation in wet conditions. The polymer was produced using a substrate-independent and solvent-free process and can be applied to various substrates.
To reduce the severe health risk and the huge economic impact associated with the fomite transmission of SARS-CoV-2, an imidazolium-based zwitterionic polymer was designed, synthesized, and demonstrated to achieve contact deactivation of a human coronavirus under dry ambient conditions that resemble fomite transmission. The zwitterionic polymer further demonstrated excellent antifouling properties, reducing the adhesion of coronavirus and the formation of bacteria biofilms under wetted conditions. The polymer was synthesized using a substrate-independent and solvent-free process, leveraging an all-dry technique named initiated chemical vapor deposition (iCVD). The broad applicability of this approach was demonstrated by applying the polymer to a range of substrates that are curved and/or with high-aspect-ratio nano/microporous structures, which remained intact after the coating process. The zwitterionic polymer and the synthesis approach reported here present an effective solution to mitigate viral transmission without the need for manual disinfection, reducing the health and economic impact of the ongoing pandemic.
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