期刊
SCIENCE ADVANCES
卷 7, 期 41, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abj0864
关键词
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资金
- Military Medicine Technology Transformation Collaborative [HU0001-17-2-0009]
- Uniformed Services University of the Health Sciences (USU) ( Jones Bridge Rd., Bethesda)
- NIH [W81XWH-13-2-0054]
- VA [W81XWH-13-2-0054]
- Health Affairs [W81XWH-13-2-0054]
- The U.S. Army Medical Research Acquisition Activity (Chandler Street, Fort Detrick, USA)
- Wound Healing Foundation 3M Fellowship
- Lancer Endowed Chair in Dermatology
The study found that using full-thickness micro skin tissue columns (MSTCs) to repair wounds can accelerate re-epithelialization, but maintaining the orientation of MSTCs does not restore normal dermal architecture. This reveals an unappreciated role for tissue morphology in determining dermal remodeling outcomes.
Skin wounds are immense medical and socioeconomic burdens, and autologous skin grafting remains the gold standard for wound repair. We recently found that full-thickness micro skin tissue columns (MSTCs) can be harvested with minimal donor site morbidity, and that MSTCs applied to wounds randomly (without maintaining their natural epidermal-dermal orientation) can accelerate re-epithelialization. However, despite MSTCs containing all the cellular and extracellular contents of full-thickness skin, normal dermal architecture was not restored by random MSTCs. In this study, we developed a magnetically induced assembly method to produce constructs of densely packed, oriented MSTCs that closely resemble the overall architecture of full-thickness skin to test the hypothesis that maintaining MSTCs' orientation could further hasten healing and restore a normal dermis. Our method led to faster and more orderly re-epithelialization but unexpectedly did not improve the retention of dermal architecture, which reveals a hitherto unappreciated role for tissue morphology in determining dermal remodeling outcomes.
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