4.8 Article

Multistep mechanism of G-quadruplex resolution during DNA replication

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Summary: DHX36 belongs to the DExD/H box heli-case family and has been shown to play a role in regulating G-quadruplexes (G4s). G4s are alternative nucleic acid structures that have an impact on transcriptional and post-transcriptional levels. This review provides an overview of DHX36's structure, substrate specificity, and mechanism of action, as well as its multiple functions in cellular homeostasis, immunity, and disease.

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