期刊
SCIENCE ADVANCES
卷 8, 期 1, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abk0967
关键词
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资金
- National Science Foundation through a CAREER Award [1847729]
- UCLA Innovation Fund
- UCLA Henry Samueli School of Engineering and Applied Sciences
- National Institute on Drug Abuse [DA045550]
- National Institute of General Medical Sciences [GM138843]
- National Science Foundation [CMMI-1636136]
- Henry M. Jackson Foundation
- Stanford Genome Technology Center Distinguished Young Investigator Award
- Brain and Behavior Foundation Young Investigator Grant
- PhRMA Foundation
- Directorate For Engineering [1847729] Funding Source: National Science Foundation
- Div Of Electrical, Commun & Cyber Sys [1847729] Funding Source: National Science Foundation
A flexible field-effect transistor biosensor array was developed to track and monitor the stress biomarker cortisol present in sweat at low concentrations. The array utilized a cortisol aptamer coupled to nanometer-thin-film In2O3 FETs to transduce molecular recognition into electrical signals, enabling real-time cortisol sweat sensing.
Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol-a key stress biomarker-is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array that exploits a previously unreported cortisol aptamer coupled to nanometer-thin-film In2O3 FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array-based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing.
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