相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
Chuan Hong et al.
NATURE COMMUNICATIONS (2021)
Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling
Hadar Israeli et al.
SCIENCE (2021)
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
Jesse I. Mobbs et al.
PLOS BIOLOGY (2021)
Structural basis of Gs and Gi recognition by the human glucagon receptor
Anna Qiao et al.
SCIENCE (2020)
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells
Adrian E. Morelli et al.
CELL REPORTS (2020)
Structural features of activated GPCR signaling complexes
Jingjing Wang et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)
Single-particle cryo-EM structural studies of the β2AR-Gs complex bound with a full agonist formoterol
Yanan Zhang et al.
CELL DISCOVERY (2020)
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
Kuglae Kim et al.
CELL (2020)
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta(1)-Adrenergic Receptor
Minfei Su et al.
MOLECULAR CELL (2020)
Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
Shuanghong Chen et al.
NATURE COMMUNICATIONS (2019)
Illuminating G-Protein-Coupling Selectivity of GPCRs
Asuka Inoue et al.
CELL (2019)
Neurokinin-1 receptor antagonists: review of their role for the prevention of chemotherapy-induced nausea and vomiting in adults
Meinolf Karthaus et al.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2019)
State-dependent Lipid Interactions with the A2a Receptor Revealed by MD Simulations Using In Vivo-Mimetic Membranes
Wanling Song et al.
STRUCTURE (2019)
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
Jendrik Schoeppe et al.
NATURE COMMUNICATIONS (2019)
MolProbity: More and better reference data for improved all-atom structure validation
Christopher J. Williams et al.
PROTEIN SCIENCE (2018)
Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein
Javier Garcia-Nafria et al.
ELIFE (2018)
Real-space refinement in PHENIX for cryo-EM and crystallography
Pavel V. Afonine et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2018)
PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Hsin-Yung Yen et al.
NATURE (2018)
Development of an antibody fragment that stabilizes GPCR/G-protein complexes
Shoji Maeda et al.
NATURE COMMUNICATIONS (2018)
Crystal structure of the human NK1 tachykinin receptor
Jie Yin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
Shawn Q. Zheng et al.
NATURE METHODS (2017)
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
Ali Punjani et al.
NATURE METHODS (2017)
Mini-G proteins: Novel tools for studying GPCRs in their active conformation
Rony Nehme et al.
PLOS ONE (2017)
Structural Basis for G Protein-Coupled Receptor Activation
Aashish Manglik et al.
BIOCHEMISTRY (2017)
Gctf: Real-time CTF determination and correction
Kai Zhang
JOURNAL OF STRUCTURAL BIOLOGY (2016)
Biased Gs Versus Gq Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network
Louise Valentin-Hansen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Universal allosteric mechanism for Gα activation by GPCRs
Tilman Flock et al.
NATURE (2015)
Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions
Erika Pinter et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2014)
Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid
Louise Valentin-Hansen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
TACHYKININS AND THEIR RECEPTORS: CONTRIBUTIONS TO PHYSIOLOGICAL CONTROL AND THE MECHANISMS OF DISEASE
Martin S. Steinhoff et al.
PHYSIOLOGICAL REVIEWS (2014)
Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies
Emiliangelo Ratti et al.
JOURNAL OF PSYCHOPHARMACOLOGY (2013)
The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A2A Adenosine G Protein-Coupled Receptor
Hugo Gutierrez-de-Teran et al.
STRUCTURE (2013)
Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting
Richard Hargreaves et al.
PHARMACEUTICAL SCIENCE TO IMPROVE THE HUMAN CONDITION: WINNERS AND FINALIST CANDIDATES OF THE PRIX GALIEN USA, INTERNATIONAL, AND PRO BONO HUMANITARIAN AWARDS 2010 (2011)
Tachykinin receptors antagonism for asthma: a systematic review
Renata Ramalho et al.
BMC PULMONARY MEDICINE (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic Strategy
Sonja Staender et al.
PLOS ONE (2010)
A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor
Michael A. Hanson et al.
STRUCTURE (2008)
Neurokinin 1 receptor antagonists:: Correlation between in vitro receptor interaction and in vivo efficacy
Erik Lindstroem et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists
T Hoffmann et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity
K Monastyrskaya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
NK1 receptor fused to β-arrestin displays a single-component, high-affinity molecular phenotype
L Martini et al.
MOLECULAR PHARMACOLOGY (2002)
The tachykinin peptide family
C Severini et al.
PHARMACOLOGICAL REVIEWS (2002)
Molecular characterization of the substance P•neurokinin-1 receptor complex -: Development of an experimentally based model
M Pellegrini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis
B Holst et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Substance P: a pioneer amongst neuropeptides
T Hokfelt et al.
JOURNAL OF INTERNAL MEDICINE (2001)
Parallel bioassay of 39 tachykinins on 11 smooth muscle preparations. Structure and receptor selectivity/affinity relationship
C Severini et al.
PEPTIDES (2000)
Substance P and its receptor neurokinin 1 expression in asthmatic airways
HW Chu et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2000)