期刊
CHEMISTRYSELECT
卷 7, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202103719
关键词
Cyclization; Heterocycles; Hydroxy(tosyloxy)iodobenzene; Hypervalent Iodine; Tosyloxyketones
资金
- CSIR-HRDG
Organo hypervalent iodine reagents have become attractive and versatile reagents for various chemical transformations in synthetic organic chemistry. They are milder and exhibit similar reactivity compared to toxic heavy metal reagents. Hydroxy(tosyloxy)iodobenzene, also known as Koser's reagent, is used as an environmentally sustainable alternative and has successfully contributed to the synthesis of important heterocycles.
Organo hypervalent iodine reagents are nowadays more attractive and versatile reagents for various chemical transformations in synthetic organic chemistry. These reagents are milder and having similar reactivity compared with toxic heavy metal reagents. Organo hypervalent iodine (lambda(3)) reagents are successfully utilized to prepare synthetically and biologically important heterocycles. Hydroxy(tosyloxy)iodobenzene (HTIB) also acknowledged as Koser's reagent uses as an environmentally sustainable alternative to toxic heavy metals for the numerous and valuable organic transformations. The goal of this review is to highlight the recent advancements of the HTIB especially in the construction of heterocycles with various substitution patterns in a well-organized form via tosyloxylation of ketones and oxidative cyclization methodology. This review compiles the up-to-date synthetic advancements of HTIB in the field of heterocycles.
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