An Overview on Synthesis and Biological Activity of Chalcone Derived Pyrazolines

Chalcones are alpha, beta unsaturated aromatic ketones having enone moiety and exhibit a wide array of pharmaceutical and biological activities. Chalcones possess a wide range of biological activities such as anticancer, antituberculosis, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antimalarial. Nitrogen-containing heterocyclic compounds are an extremely important class of organic compounds with a broad spectrum of pharmaceutical activities. Pyrazolines are N- heterocyclic compounds that exhibit a wide range of pharmaceutical activities and are synthesized from chalcone with enhanced biological activity. The present study summarizes the chemistry of various chalcone-based pyrazolines and their derivatives with the available data till 2021.

Automated summary

Chalcones are a group of aromatic ketones with enone moiety that exhibit a wide range of biological activities, and when synthesized into pyrazolines, their biological activity can be enhanced. This study reviews the chemistry of various chalcone-based pyrazolines and their derivatives up to 2021.