期刊
CHEMISTRYSELECT
卷 6, 期 47, 页码 13414-13418出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202103841
关键词
C-H activation; Halogenation; Mesoionic compounds; Nitrogen heterocycles; Palladium
The Pd-catalyzed bromination of mesoionic 1,3-diphenyltetrazolium-5-olate was developed, with the 4-nitrogen atom acting as a directing group. Specific conditions were used to achieve bromination, demonstrating the role of the palladium catalyst and bromine reagent in the reaction.
Pd-catalyzed bromination of mesoionic 1,3-diphenyltetrazolium-5-olate (1) was developed. In the presence of palladium acetate (5 mol%), N-bromosuccinimide (110 mol%), and p-toluenesulfonic acid (50 mol%) in 1,2-dichloroethane under reflux, olate 1 underwent bromination to give 1-(2-bromophenyl)-3-phenyltetrazolium-5-olate in a moderate yield as the major product, indicating that the 4-nitrogen atom acts as a directing group rather than the negatively charged oxygen atom. The X-ray-suitable crystals of the corresponding palladacycle were isolated from 1-mesityl-3-phentytetrazolium-5-olate and fully characterized. When both the o-positions of the 3-phenyl group were occupied by bromine atoms, o-bromination then occurred at the 1-phenyl group with the aid of the olate oxygen.
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