期刊
CHEMISTRYSELECT
卷 7, 期 3, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202103524
关键词
PLGA; nanoparticles; surface modification; tumor targeting; drug delivery
资金
- National Natural Science Foundation of China [21877100, 22177104, 21708034]
- Fundamental Research Funds for the Provincial Universities of Zhejiang [RF-B2019003]
Poly(lactic-co-glycolic acid) (PLGA) is an FDA-approved polymer known for its biocompatibility and biodegradability. PLGA-based nanoparticles (NPs) have shown potential as drug delivery systems, but their lack of selectivity to cancer cells limits their clinical application. This review summarizes passive and active tumor-targeting strategies using PLGA NPs for drug delivery, and discusses new challenges and opportunities for further research.
Poly(lactic-co-glycolic acid) (PLGA) is an FDA-approved polymer for its biocompatibility and biodegradability. PLGA-based nanoparticles (NPs) are well recognized as promising candidates for drug delivery. However, the lack of selectivity to cancer cells limits the clinical application of PLGA-based NPs. In recent years, a number of studies were focused on tackling this limitation and showed great potential in improving the anticancer efficacy. Herein, we summarize passive tumor-targeting strategies through the EPR effect and active tumor-targeting strategies through ligand modifications based on PLGA NPs for tumor-targeted drug delivery. Finally, new challenges and possible opportunities for further research are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据