期刊
CHEMISTRYSELECT
卷 6, 期 47, 页码 13384-13408出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202103407
关键词
CF3 radical; CF3 source; Direct C-H trifluoromethylation; N-Heterocycles; Radical mechanism
资金
- CSIR, New Delhi [OLP 2054]
Fluorine chemistry plays a crucial role in various industries, and incorporating fluorine atoms can enhance the properties of organic compounds. Specifically, molecules with trifluoromethyl groups exhibit diverse pharmacological and biological properties. Recent research has focused on direct trifluoromethylation of important N-heterocycles involving CF3 radicals.
Fluorine chemistry executes a vital role in the agricultural, pharmaceutical, and materials industries. Moreover, introducing fluorine atom and fluorine-containing groups onto organic compounds can enhance the chemical and physical properties of the parent molecules. Because of this reason, researchers have been putting continuous efforts into developing newer and practical methodologies to incorporate fluorinated groups into organic molecules. Mainly, molecules bearing the trifluoromethyl (-CF3) group show various pharmacological and biological properties. The current review provides comprehensive coverage of the recent development on the direct trifluoromethylation of some essential N-heterocycles involving CF3 radicals.
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