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Graphene Biodevices for Early Disease Diagnosis Based on Biomarker Detection

期刊

ACS SENSORS
卷 6, 期 11, 页码 3841-3881

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acssensors.1c01172

关键词

biodevices; early diagnosis; biomarker detection; graphene; functionalization; field-effect transistors; electrochemical biosensors; optical biosensors; microfluidic system; circulating tumor cells

资金

  1. National Key Research and Development Program of China [2017YFB0405400]
  2. Project of 20 items of University of Jinan [2018GXRC031]
  3. National Natural Science Foundation of China [51802116]
  4. Natural Science Foundation of Shandong Province, China [ZR2019BEM040]
  5. NSFC [52022037, 52071225]
  6. Taishan Scholars Project Special Funds [TSQN201812083]
  7. National Science Center
  8. Czech Republic under the ERDF program Institute of Environmental Technology-Excellent Research [CZ.02.1.01/0.0/0.0/16_019/0000853]
  9. Sino-German Research Institute [GZ 1400]

向作者/读者索取更多资源

This paper discusses the vital role of graphene-based biosensors in early disease diagnosis, introducing the development background and key technologies of this technology, as well as its applications in detecting biomarkers.
The early diagnosis of diseases plays a vital role in healthcare and the extension of human life. Graphene-based biosensors have boosted the early diagnosis of diseases by detecting and monitoring related biomarkers, providing a better understanding of various physiological and pathological processes. They have generated tremendous interest, made significant advances, and offered promising application prospects. In this paper, we discuss the background of graphene and biosensors, including the properties and functionalization of graphene and biosensors. Second, the significant technologies adopted by biosensors are discussed, such as field-effect transistors and electrochemical and optical methods. Subsequently, we highlight biosensors for detecting various biomarkers, including ions, small molecules, macromolecules, viruses, bacteria, and living human cells. Finally, the opportunities and challenges of graphene-based biosensors and related broad research interests are discussed.

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