期刊
MOLECULAR THERAPY-ONCOLYTICS
卷 24, 期 -, 页码 663-682出版社
CELL PRESS
DOI: 10.1016/j.omto.2022.02.004
关键词
-
资金
- Russian Science Foundation [20-15-0167]
This article summarizes the data on the infection of non-cancer cells by oncolytic viruses, with a focus on tumor microenvironment and secondary lymphoid tissues. The article aims to address two major questions: how attenuated viruses infect normal cells and whether it is important for oncolytic virotherapy.
Oncolytic viruses are designed to specifically target cancer cells, sparing normal cells. Although numerous studies demonstrate the ability of oncolytic viruses to infect a wide range of non-tumor cells, the significance of this phenomenon for cancer viro- therapy is poorly understood. To fill the gap, we summarize the data on infection of non-cancer targets by oncolytic viruses with a special focus on tumor microenvironment and secondary lymphoid tissues. The review aims to address two major questions: how do attenuated viruses manage to infect normal cells, and whether it is of importance for oncolytic virotherapy.
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