期刊
FRONTIERS IN PEDIATRICS
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2021.797684
关键词
retinopathy of prematurity; pediatric retina; optical coherence tomography; handheld optical coherence tomography; optical coherence tomography with angiography
类别
资金
- National Institutes of Health (Bethesda, MD) [R01 HD107494, P30 EY10572]
- Research to Prevent Blindness (New York, NY)
- West Coast Consortium for Technology and Innovations in Pediatrics
Advancements in portable OCT and OCTA have expanded the clinical role of OCT technology in ROP diagnosis and management, allowing for objective diagnosis, disease monitoring, mapping of vascular development, and dye-free visualization.
Recent advances in portable optical coherence tomography (OCT) and OCT angiography (OCTA) have resulted in wider fields of view (FOV) and shorter capture times, further expanding the potential clinical role of OCT technology in the diagnosis and management of retinopathy of prematurity (ROP). Using a prototype, handheld OCT device, retinal imaging was obtained in non-sedated infants in the neonatal intensive care unit (NICU) as well as sedated infants in the operating room of Oregon Health & Science University (OHSU) Hospital. In this observational study, we provide an overview of potential advantages of OCT-based disease assessment in ROP. We observed that next-generation OCT imaging (a) may be sufficient for objective diagnosis and zone/stage/plus disease categorization, (b) allows for minimally-invasive longitudinal monitoring of disease progression and post-treatment course, (c) provides three-dimensional mapping of the vitreoretinal interface, and (d) with OCTA, enables dye-free visualization of normal and pathologic vascular development.
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