期刊
FRONTIERS IN PEDIATRICS
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2021.804496
关键词
congenital diaphragmatic hernia (CDH); diaphragm; pleuroperitoneal folds; perivascular cells; mesothelium
类别
资金
- Sophia Foundation for Scientific Research [S17-20]
Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by diaphragmatic defect, lung hypoplasia, and structural vascular defects. Despite recent developments, the pathogenesis of CDH remains poorly understood. It is a complex congenital disorder with multifactorial etiology involving genetic, cellular, and mechanical factors.
Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.
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