期刊
FRONTIERS IN PEDIATRICS
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2021.796143
关键词
ROP; OIR; VEGF; VEGFRs; VEGF receptors; neuropilins
类别
资金
- National Institutes of Health/National Eye Institute [F30EY032311, P30EY014800, R01EY015130, R01EY017011]
- Research to Prevent Blindness, New York, NY
ROP is a leading cause of blindness in children worldwide. Concerns exist regarding the optimal doses of anti-VEGF for individual infants and the effect of broad VEGF inhibition on physiologic angiogenesis. Understanding VEGF signaling in both physiologic and pathologic angiogenesis in the retina is crucial.
Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide. Blindness can occur from retinal detachment caused by pathologic retinal angiogenesis into the vitreous, termed intravitreal neovascularization (IVNV). Although agents that interfere with the bioactivity of vascular endothelial growth factor (VEGF) are now used to treat IVNV, concerns exist regarding the identification of optimal doses of anti-VEGF for individual infants and the effect of broad VEGF inhibition on physiologic angiogenesis in external organs or in the retina of a preterm infant. Therefore, it is important to understand VEGF signaling in both physiologic and pathologic angiogenesis in the retina. In this manuscript, we review the role of receptors that interact with VEGF in oxygen-induced retinopathy (OIR) models that represent features of ROP pathology. Specifically, we discuss our work regarding the regulation of VEGFR2 signaling in retinal endothelial cells to not only reduce severe ROP but also facilitate physiologic retinal vascular and neuronal development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据