4.7 Article

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Food Science & Technology

Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases

William T. Festuccia

Summary: Evidence suggests that lipotoxicity and inflammation are key factors linking adipose tissue dysfunction to metabolic diseases, with mTOR playing a crucial role in regulating adipocyte and macrophage function. Studies reviewed here show that optimal levels of mTORC1 activity are necessary for lipogenic actions in adipocytes, while mTORC1 also regulates polarization in macrophages. On the other hand, mTORC2 promotes glucose uptake and lipogenesis in adipocytes while dampening macrophage inflammatory response.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

Article Biochemistry & Molecular Biology

Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p

Maria A. Ahonen et al.

Summary: miR-221-3p overexpression inhibits terminal differentiation of adipocytes, while its inhibitor increases triglyceride storage. The effects of miR-221-3p may be mediated through 14-3-3 gamma, and it also impacts lipid metabolism.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

Article Medicine, Research & Experimental

被撤回的出版物: Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4 (Retracted article. See vol. 306, 2022)

Haiyu Zhang et al.

Summary: By regulating miR-222, the action of CXCR4 can be promoted, and the activation of NLRP3 inflammasomes can be inhibited, thereby alleviating the inflammatory response in gestational diabetes mellitus patients.

LIFE SCIENCES (2021)

Review Immunology

Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases

Zhe Huang et al.

Summary: Adipose tissue is a complex organ that regulates energy metabolism and insulin sensitivity, in part by secreting adipokines that participate in immune responses and metabolic regulation. Adipose-derived extracellular vesicles, including exosomes and microvesicles, act as signal messengers that mediate intercellular communication and tissue remodeling within the body. These vesicles also play a role in sending genetic information, mainly in the form of microRNAs, to target cells in distal organs for regulation of gene expression.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Ezetimibe ameliorates lipid accumulation during adipogenesis by regulating the AMPK-mTORC1 pathway

Yu Seol Lee et al.

FASEB JOURNAL (2020)

Article Cell Biology

MicroRNA miR-222 mediates pioglitazone beneficial effects on skeletal muscle of diet-induced obese mice

Mariana de Mendonca et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)

Review Biochemistry & Molecular Biology

mTOR Pathway is Involved in Energy Homeostasis Regulation as a Part of the Gut-Brain Axis

Veronica Pena-Leon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

A MicroRNA Linking Human Positive Selection and Metabolic Disorders

Lifeng Wang et al.

Review Cell Biology

Is REDD1 a metabolic double agent? Lessons from physiology and pathology

Florian A. Britto et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

MicroRNA-425 controls lipogenesis and lipolysis in adipocytes

Renli Qi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2019)

Article Medicine, Research & Experimental

Knockdown of miR-222 inhibits inflammation and the apoptosis of LPS-stimulated human intervertebral disc nucleus pulposus cells

Yang Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Review Medicine, Research & Experimental

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

C. Ronald Kahn et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Medicine, Research & Experimental

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

Yong Pan et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Multidisciplinary Sciences

Identification of microRNA that represses IRS-1 expression in liver

Kaoru Ono et al.

PLOS ONE (2018)

Review Biochemistry & Molecular Biology

Role of mTOR Signaling in Tumor Microenvironment: An Overview

Fabiana Conciatori et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Endocrinology & Metabolism

Identification of Circulating miR-101, miR-375 and miR-802 as Biomarkers for Type 2 Diabetes

Chigusa Higuchi et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2015)

Article Hematology

MicroRNAs modulate the angiogenic properties of HLTVECs

Laura Poliseno et al.