4.7 Review

Association of Estrogen Receptor Genes Polymorphisms With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Based on Observational Studies

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Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
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