4.7 Article

Spermine Regulates Immune and Signal Transduction Dysfunction in Diabetic Cardiomyopathy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Spermine Protects Cardiomyocytes from High Glucose-Induced Energy Disturbance by Targeting the CaSR-gp78-Ubiquitin Proteasome System

Yuehong Wang et al.

Summary: The study found that spermine plays a protective role in energy metabolism disorder and diabetic cardiomyopathy (DCM) by modulating the CaSR protein level and gp78 activation. High glucose decreased the endogenous content of spermine and led to detrimental effects on mitochondrial communication and ATP levels. This suggests that spermine could be a potential target for the prevention and treatment of DCM.

CARDIOVASCULAR DRUGS AND THERAPY (2021)

Article Medicine, Research & Experimental

Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang et al.

Summary: This study found that the progression of diabetic nephropathy is influenced by the polyamine metabolic pool, particularly the decrease in spermine content. High glucose can lead to increased kidney weight, abnormal kidney function, increased urinary albumin excretion, mesangial thickening, and loss or fusion of podocytes.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

Ryanodine receptor and immune-related molecules in diabetic cardiomyopathy

Cheng-Ju Tian et al.

Summary: Hyperglycaemia is a major factor in diabetic cardiomyopathy, leading to increased levels of reactive species in the heart. Ryanodine receptors play a key role in heart contractions, and inflammation is influenced by IL-1 signals.

ESC HEART FAILURE (2021)

Article Biochemistry & Molecular Biology

Lipids that directly regulate innate immune signal transduction

Katherine C. Barnett et al.

INNATE IMMUNITY (2020)

Review Cardiac & Cardiovascular Systems

The adaptive immune role of metallothioneins in the pathogenesis of diabetic cardiomyopathy: good or bad

Tingwen Ge et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

Editorial Material Cardiac & Cardiovascular Systems

Diabetic Cardiomyopathy What Is It and Can It Be Fixed?

Wolfgang H. Dillmann

CIRCULATION RESEARCH (2019)

Review Biochemistry & Molecular Biology

Cardiomyopathy Associated with Diabetes: The Central Role of the Cardiomyocyte

Tiziana Filardi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cardiac & Cardiovascular Systems

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

Dongchao Lu et al.

NATURE REVIEWS CARDIOLOGY (2019)

Article Endocrinology & Metabolism

Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice

Yu Sun et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

Article Biochemical Research Methods

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen et al.

BIOINFORMATICS (2018)

Article Biotechnology & Applied Microbiology

Differences between fast and slow muscles in scallops revealed through proteomics and transcriptomics

Xiujun Sun et al.

BMC GENOMICS (2018)

Review Biochemistry & Molecular Biology

Targeting Transcription Factors for Cancer Treatment

Melanie Lambert et al.

MOLECULES (2018)

Review Endocrinology & Metabolism

Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease

Guanghong Jia et al.

DIABETOLOGIA (2018)

Article Biochemistry & Molecular Biology

KEGG: new perspectives on genomes, pathways, diseases and drugs

Minoru Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2017)

Review Cardiac & Cardiovascular Systems

Immune mechanisms in heart failure

Yingying Zhang et al.

EUROPEAN JOURNAL OF HEART FAILURE (2017)

Review Biochemistry & Molecular Biology

Targeting polyamine metabolism for cancer therapy and prevention

Tracy R. Murray-Stewart et al.

BIOCHEMICAL JOURNAL (2016)

Article Pharmacology & Pharmacy

Targeting transcription factors by small compounds-Current strategies and future implications

Judith Hagenbuchner et al.

BIOCHEMICAL PHARMACOLOGY (2016)

Article Biochemistry & Molecular Biology

Endogenous polyamine function-the RNA perspective

Helen L. Lightfoot et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Mammalian Polyamine Metabolism and Function

Anthony E. Pegg

IUBMB LIFE (2009)

Article Biochemical Research Methods

Mapping and quantifying mammalian transcriptomes by RNA-Seq

Ali Mortazavi et al.

NATURE METHODS (2008)