期刊
FRONTIERS IN ENDOCRINOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.801689
关键词
obstructive sleep apnea; aldosterone; hypertension; continuous positive airway pressure (CPAP); mineralocorticoid receptor antagonists
资金
- National Natural Science Foundation of China [82070089, 81770084]
- Shanghai Municipal Key Clinical Specialty [shslczdzk02202]
- Shanghai Top-Priority Clinical Key Disciplines Construction Project [2017ZZ02014]
- Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases [20dz2261100]
- Cultivation Project of Shanghai Major Infectious Disease Research Base [20dz2210500]
Obstructive sleep apnea (OSA) is an independent risk factor for hypertension, and the underlying mechanisms include oxidative stress, endothelial injury, sympathetic excitement, and renin-angiotensin-aldosterone system activation. Clinical studies have shown a high coexistence of OSA and primary aldosteronism in hypertensive patients, and elevated aldosterone levels are independently associated with OSA severity in resistant hypertension.
Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin-angiotensin-aldosterone system activation, etc. Clinical studies have found that there is a high coexistence of OSA and primary aldosteronism in patients with hypertension and that elevated aldosterone levels are independently associated with OSA severity in resistant hypertension. The underlying mechanism is that aldosterone excess can exacerbate OSA through increasing overnight fluid shift and affecting the mass and function of upper airway muscles during the sleep period. Thus, a bidirectional influence between OSA and aldosterone exists and contributes to hypertension in OSA patients, especially resistant hypertension.
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