Correlation Analysis Between Ovarian Reserve and Thyroid Hormone Levels in Infertile Women of Reproductive Age

Objective To analyze the correlation between ovarian reserve and thyroid function in women with infertility. Methods Retrospective analysis of the data of 496 infertility patients who visited the clinic between January 2019 and December 2020. According to the TSH level, it is grouped into < 2.5 mIU/L, 2.5 similar to 4.0mIU/L and >= 4.0 mIU/L or according to the positive/negative thyroid autoimmune antibody. The relationship was assessed through the ovarian reserve, thyroid function, and anti-Mullerian hormone (AMH) levels in infertile patients. On the other hand, the patients are divided into groups according to age (<= 29 years old, 30-34 years old and >= 35 years old), basic FSH (< 10 IU/L and >= 10 IU/L), and AMH levels. The ovarian reserve was evaluated through the AMH and the antral follicle count (AFC). Results The average age of the patients was 30.31 +/- 4.50 years old, and the average AMH level was 5.13 +/- 4.30 ng/mL. 3.63% (18/496) of patients had abnormal TSH levels (normal: 0.35-5.5 mIU/L), the positive rate of thyroid peroxidase antibody (TPOAb) was 14.52% (72/496), the positive rate of anti-thyroglobulin antibody (TgAb) was 16.94% (84/496), and the positive rate of TPOAb and TgAb was 10.48% (52/496). After grouping according to TSH level or thyroid autoimmune antibody positive/negative grouping, the analysis found that there was no statistical significance in age, AMH level and basic FSH level among the groups (P > 0.05). There were no significant differences in the levels of TSH, FT3, and FT4 among different ages, AMH, and FSH levels (P > 0.05). Conclusion There is no significant correlation between ovarian reserve and thyroid function in infertile women.

Automated summary

The analysis of data from 496 infertile patients showed no significant correlation between ovarian reserve and thyroid function in infertile women, whether grouped based on TSH levels or thyroid autoimmune antibodies.