PPP1R14B Is a Prognostic and Immunological Biomarker in Pan-Cancer

Recent studies have shown that PPP1R14B was highly expressed in tumor tissues and patients with high expression of PPP1R14B had poor survival rates. However, the function and mechanisms of PPP1R14B in tumor progression remain ill defined. There was also lack of pan-cancer evidence for the relationship between PPP1R14B and various tumor types based on abundant clinical data. We used the TCGA project and GEO databases to perform pan-cancer analysis of PPP1R14B, including expression differences, correlations between expression levels and survival, genetic alteration, immune infiltration, and relevant cellular pathways, to investigate the functions and potential mechanisms of PPP1R14B in the pathogenesis or clinical prognosis of different cancers. Herein, we found that PPP1R14B was involved in the prognosis of pan-cancer and closely related to immune infiltration. Increased PPP1R14B expression correlated with poor prognosis and increased immune infiltration levels in myeloid-derived suppressor cells (MDSCs). Our studies suggest that PPP1R14B can be used as a prognostic biomarker for pan-cancer. Our findings may provide an antitumor strategy targeting PPP1R14B, including manipulation of tumor cell growth or the tumor microenvironment, especially myeloid-derived suppressor cell infiltration.

Automated summary

Recent studies have shown that high expression of PPP1R14B in tumor tissues is associated with poor survival rates. However, the exact function and mechanisms of PPP1R14B in tumor progression are still unclear. In this study, pan-cancer analysis of PPP1R14B using TCGA project and GEO databases revealed its involvement in cancer prognosis and close relationship with immune infiltration, especially myeloid-derived suppressor cell infiltration. These findings suggest PPP1R14B can serve as a prognostic biomarker for pan-cancer and may be a target for anti-tumor strategies.