期刊
FRONTIERS IN GENETICS
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.774922
关键词
MHC; HLA; association analysis; SARS- CoV-2; COVID-19; immunogenetics
资金
- European Union [846520]
- ATIP-Avenir Inserm program, the Region Pays de Loire ConnectTalent
- National Institutes of Health (NIH) National Institute of Allergy and Infectious Disease (NIAID) [R01AI128775, R01AI159260]
- Marie Curie Actions (MSCA) [846520] Funding Source: Marie Curie Actions (MSCA)
Researchers have investigated the role of MHC/HLA polymorphism in SARS-CoV-2 infection and COVID-19 progression to support and unify related efforts. They have reviewed HLA immunogenomics studies and reflected on the role of various HLA data, their limitations, and future prospects.
The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics' interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.
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