Comparative Study of Perioperative and Oncological Outcomes Between Elderly Patients and Younger Patients Who Received Radical Cystectomy and Pelvic Lymph Node Dissection: A Single-Center Retrospective Study

Purpose: To compare the perioperative and survival outcomes of patients over 75 years and younger patients who received radical cystectomy. Patients and methods: A total of 119 patients aged 0.001). Age 75 years was a risk factor for overall survival (HR = 1.69 [95% CI: 1.22-2.35]; p = 0.002) and progression-free survival (HR = 1.69 [95% CI: 1.14- 2.50]; p = 0.008) for patients who received radical cystectomy but was not a poor risk factor for major complications (HR = 1.25 [95% CI: 0.47-3.31]; p = 0.658) after radical cystectomy. In addition, preoperative renal insufficiency was associated with a higher risk of major complications. Conclusion: In our cohort, compared with younger patients, elderly patients aged >75 years had worse survival outcomes, but age >75 years was not a risk factor for major complications after radical cystectomy with pelvic lymph node dissection. Radical surgery should be encouraged for elderly patients who can tolerate aggressive treatments.

Automated summary

The study compared the perioperative and survival outcomes of patients over 75 years and younger patients who received radical cystectomy. It found that elderly patients aged >75 had worse survival outcomes, but age >75 was not a risk factor for major complications after radical cystectomy.