期刊
SCIENCE CHINA-MATERIALS
卷 65, 期 3, 页码 845-854出版社
SCIENCE PRESS
DOI: 10.1007/s40843-021-1770-0
关键词
antibiotic-free materials; carbon dots; intrinsic anti-bacterial activities; MRAB biofilm eradication
资金
- National Natural Science Foundation of China (NSFC) [21925802, 21878039, 21808028, 22022803, 22078046]
- NSFC-Liaoning United Fund [U1908202]
- National Key Research and Development Plan [2018AAA0100301]
Red-carbon dots (R-CDs) synthesized in this study show intrinsic antibacterial activities and can effectively kill multidrug-resistant bacteria by generating reactive oxygen species. They can also inhibit the formation of MRAB biofilms with minimal side effects on normal cells. Furthermore, R-CDs have demonstrated potential in treating antibiotic-sensitive MRAB-induced infected wounds, suggesting a promising strategy for designing next-generation agents against drug-resistant bacteria.
The emergence of antibiotic resistance in bacteria is a major public-health issue. Synthesis of efficient antibiotic-free material is very important for fighting bacterial infection-related diseases. Herein, red-carbon dots (R-CDs) with a broad range of spectral absorption (350-700 nm) from organic bactericides or intermediates were synthesized through a solvothermal route. The prepared R-CDs not only had intrinsic antibacterial activities, but also could kill multidrug-resistant bacteria (multidrug-resistant Acinetobacter baumannii (MRAB) and multidrug-resistant Staphylococcus aureus (MRSA)) effectively by generating reactive oxygen species. Furthermore, R-CDs could eliminate and inhibit the formation of MRAB biofilms, while conferring few side effects on normal cells. A unique property of R-CDs was demonstrated upon in vivo treatment of antibiotic-sensitive MRAB-induced infected wounds. These data suggested that this novel R-CDs-based strategy might enable the design of next-generation agents to fight drug-resistant bacteria.
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