期刊
FRONTIERS IN CHEMISTRY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2021.771801
关键词
TLC; MALDI; ambient ionization mass spectrometry (AIMS); sorbents; derivatization
资金
- Russian Science Foundation [21-73-20032]
- Russian Science Foundation [21-73-20032] Funding Source: Russian Science Foundation
The combination of planar chromatography with desorption/ionization mass-spectrometry techniques provides chemists with fast and simple separation of mixtures followed by detection of analytes. Since its introduction in the early 1990s, thin-layer chromatography/matrix-assisted mass spectrometry has been widely used for analyzing natural and synthetic organic compounds. New desorption/ionization approaches have been developed and applied in recent years, competing with MALDI.
The combination of planar chromatography with desorption/ionization mass-spectrometry (MS) techniques provides chemists with unique tools for fast and simple separation of mixtures followed by the detection of analytes by the most powerful analytical method. Since its introduction in the early 1990s, thin-layer chromatography (TLC)/matrix-assisted mass spectrometry (MALDI) has been used for the analysis of a wide range of analytes, including natural and synthetic organic compounds. Nowadays, new desorption/ionization approaches have been developed and applied in conjunction with planar chromatography competing with MALDI. This review covers recent developments in the combination of TLC with various desorption/ionization MS methods which were made in recent several years.
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