期刊
FRONTIERS IN CHEMISTRY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2021.780608
关键词
dendrimers; oligonucleotides; hydrogel; polyelectrolyte complexes; controlled release
This study presents the method of impregnating neutral hydrogels with siRNA-dendrimer complexes, where the surface chemistry of dendrimers allows adjustment of the release rate. This provides a new material for biomedical applications.
Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA-dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.
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