期刊
FRONTIERS IN CHEMISTRY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2021.831173
关键词
Corydalis yanhusuo; seco-isoquinoline alkaloid; secoyanhusamine A; acetylcholinesterase inhibitor; Alzheimer's disease
资金
- Beijing Natural Science Foundation [JQ18026]
- National Natural Science Foundation of China (NNSFC) [82073978, 81760783, 81522050]
- Innovation team of Medicinal Material Resource Protection and High Value Utilization in Qinghai Province [2021XJPI02]
Secoyanhusamine A, a rare rearranged seco-isoquinoline alkaloid derived from Corydalis yanhusuo tubers, exhibits potent inhibition against acetylcholinesterase. It possesses a highly oxidized isoquinoline inner salt structure.
Secoyanhusamine A (1), a rare rearranged seco-isoquinoline alkaloid derived from ring oxidative cleavage, was isolated from an aqueous extract of Corydalis yanhusuo tubers, together with its biosynthetic precursor dehydrocorybulbine (2). Secoyanhusamine A (1) was the first example of a highly oxidized isoquinoline inner salt resulting in a 5-(2-azanylethyl)-2-carboxylate-4-oxo-4H-pyran ring system. The biosynthetic pathway of 1 was also postulated. Secoyanhusamine A (1) exhibited potent inhibition against acetylcholinesterase (AChE) with an IC50 value of 0.81 +/- 0.13 mu M. Molecular simulation docking demonstrated that 1 created a strong interaction with the Asp-74 residue of AChE via attractive charge of the quaternary nitrogen.
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