期刊
MATERIALS & DESIGN
卷 215, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2022.110477
关键词
Magnesium phosphate; Polycaprolactone; 3D print; Maxillofacial bone; In situ
资金
- Liaoning Province [3110517007]
- Clinical Research Foundation of Inner Mongolia Stomatological Association [IMSA-2019-C5]
- Chifeng College serves Chifeng economic and social development application project [CFXYFC201861]
The PCL#20MgP scaffold prepared by 3D printing technology has strong ability to promote osteogenic differentiation and bone formation, which is suitable for the repair of maxillofacial bone defects.
The development of a scaffold that can be quickly prepared and used to repair maxillofacial bone defects is an urgent clinical need. 3D printing technology can prepare personalized bone defect substitutes according to the computed tomography (CT) data of the patient's defect location. Magnesium is a bioactive molecule that plays an important role in the process of bone repair. In this study, different contents of magnesium phosphate (Mg-3(PO4)(2)) were incorporated into polycaprolactone (PCL), and a bone defect repair scaffold was prepared using 3D printing technology. In vitro results showed that PCL scaffolds containing 20 % Mg-3(PO4)(2) (PCL#20MgP) had the strongest ability to promote osteogenic differentiation. Micro-CT and histological staining results of the repair of tibial defects in rats also further proved that the PCL#20MgP scaffold had strong bone formation ability in vivo. The PCL#20MgP scaffold was used to repair the rabbit maxillofacial bone defect. The Micro-CT results also confirmed that PCL#20MgP had a better osteogenesis effect than the PCL scaffold. The PCL#20MgP scaffold has good clinical application prospects in the field of maxillofacial bone defect repair. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据